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Diss Factsheets
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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 217 (Soil Microorganisms: Carbon Transformation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Test material form:
- other: Amber liquid
- Details on test material:
- - Name of test material (as cited in study report):Kathon(TM) 886F biocide
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 6111L019
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: Stable at room temperature
- Solubility and stability of the test substance in the solvent/vehicle: Soluble and stable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dilution in water
- Final dilution of a dissolved solid, stock liquid or gel: 1, 10, 50, 100 and 500 mg CMIT/MIT per kg dry weight soil
OTHER SPECIFICS: Purity of test material was 14%
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- AMENDMENT OF SOIL
- Type of organic substrate: glucose-amended soil
APPLICATION OF TEST SUBSTANCE TO SOIL
- Method: TS was applied to the soil in aqueous solution. TS and soil were mixed.
VEHICLE:
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Water
- Concentration of vehicle in test medium (stock solution and final test solution): Not applicable
- Evaporation of vehicle before use: Not applicable
Test organisms
- Test organisms (inoculum):
- soil
Study design
- Total exposure duration:
- 28 d
Test conditions
- Test temperature:
- 20 ± 2 °C
- Moisture:
- 40-70 %
- Details on test conditions:
- TEST SYSTEM
- Testing facility: Wildlife International
- Test container (type, material, size): Glass container
- Amount of soil: 400 g
- No. of replicates per concentration: 3
- No. of replicates per control: 3
- No. of replicates per vehicle control: n/a
SOIL INCUBATION
- Method: bulk
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Geographical reference of sampling site (latitude, longitude): Grand Forks County, North Dakota, USA (latitude N 47º 48.141’, longitude 097º 37.241’)
- History of site: Pine tree forest
- Treatments with pesticides or fertilizers: No crop protection products or fertilizers for at least 10 years
- Accidental contamination: Not described
- Depth of sampling: 0-6 inches
- Soil texture
- % sand: 71%
- % silt: 12%
- % clay: 17%
- Soil taxonomic classification: Sandy loam soil
- Soil classification system: Not described
- pH (in water): 6.8
- Initial nitrate concentration for nitrogen transformation test (mg nitrate/kg dry weight): 0.138 %
- Maximum water holding capacity (in % dry weigth): 40 to 70 %
- Cation exchange capacity (mmol/kg): Not described
- Pretreatment of soil: Sieving through a 2 mm sieve
- Storage (condition, duration): The soil was stored refrigerated then brought to room temperature to reduce soil moisture content
- Initial microbial biomass as % of total organic C: approximately 1.9 %
DETAILS OF PREINCUBATION OF SOIL (if any): n/a
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Measurements of carbon dioxide release were performed approximately every 2 hours over a 12-hour period.
VEHICLE CONTROL PERFORMED: no - Nominal and measured concentrations:
- Nominal concentrations: 1, 10, 50, 100, and 500 mg CMIT/MIT per kg dry weight soil
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- respiration rate
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.04 mg/kg soil dw
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- act. ingr.
- Basis for effect:
- respiration rate
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 38.6 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- respiration rate
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 1.55 mg/kg soil dw
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- act. ingr.
- Basis for effect:
- respiration rate
- Duration:
- 28 d
- Dose descriptor:
- EC25
- Effect conc.:
- 19.1 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- respiration rate
- Duration:
- 28 d
- Dose descriptor:
- EC10
- Effect conc.:
- 7.7 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- respiration rate
- Details on results:
- - Effect concentrations exceeding solubility of substance in test medium: No
- Reported statistics and error estimates:
- The respiration rates of the treated soil samples after 28 days were compared to that of the control soil samples and the percent inhibition of each test concentration was calculated using “TOXSTAT Release 3.5”. Statistical procedures were used to calculate EC10, EC25 and EC50 values and 95 % confidence limits.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The nominal 28d NOEC was determined to be 1 mg a.i. /kg dry soil.
- Executive summary:
OECD 217, Effects on soil microflora carbon respiration transformation. Results of controls are in acceptable range. The variations between the replicate control sample rates of respiration measured on Day 28 was less than 15 %, fulfilling the validity criterion of the test. Greater than 50 % rate inhibition was demonstrated at test concentrations of 50, 100 and 500 mg CMIT/MIT per kg dry weight soil. The nominal 28d NOEC was determined to be 1 mg a.i. /kg dry soil.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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