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EC number: 618-690-2 | CAS number: 90982-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- other: Addendum to study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The photodegradation of [pheny1-14c(U)] DPX-F6025 and [pyrimidine-2-14c] DPX-F6025 (ethyl 2-[[[[4-chloro-6-methoxypyrimidine-2-yl)- amino]carbonyl]amino]sulfonyl]benzoate) was examined in sterilized, buffered, aqueous solutions at pH 5, 7, and 9. The rate of degradation of DPX-F6025 in samples exposed to simulated sunlight was compared to degradation of control samples kept protected from light. The temperature of all test solutions was maintained at 25°C.
- GLP compliance:
- no
Test material
- Reference substance name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- EC Number:
- 618-690-2
- Cas Number:
- 90982-32-4
- Molecular formula:
- C15H15ClN4O6S
- IUPAC Name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- Test material form:
- solid
- Remarks:
- White
- Details on test material:
- 95 to >99% purity
Constituent 1
- Specific details on test material used for the study:
- [pyrimidine-2-14c] DPX-F6025 and [phenyl-14c(U)] DPX-F6025
- Radiolabelling:
- yes
Study design
- Oxygen conditions:
- not specified
- Inoculum or test system:
- natural water
- Duration of test (contact time):
- 15 d
Initial test substance concentration
- Initial conc.:
- 5 other: ppm
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- radiochem. meas.
Results and discussion
Half-life of parent compound / 50% disappearance time (DT50)open allclose all
- Key result
- Compartment:
- other: pH 5
- DT50:
- 12 d
- Key result
- Compartment:
- other: pH 7
- DT50:
- 27 d
- Key result
- Compartment:
- other: pH 9
- DT50:
- >= 31 - <= 43 d
- Transformation products:
- yes
- Remarks:
- 4-chloro-6-methoxy-2-pyrimidinamine and Ethyl 2-aminosulfonylbenzoate
Any other information on results incl. tables
Addendum 1 Summary:
The unidentified photoproduct from the aqueous photolysis of the test substance (designated unknown 1 in AMR-456-85) has been identified as ethyl 2-[[[[(4-hydroxy-6-methoxypyrimidin-2-yl)amino]-carbonyl]amino]- sulfonyl] benzoate. At pH 9.0. this compound accounts for approximately 12% of the total radioactivity after 15 days of continuous exposure and is the only photoproduct comprising over 10% of the total radiolabel. The compound was isolated from a 200 ppm test substance solution photolyzed in PH 9.0 buffer in order to isolate enough material for characterization. The identity of Unknown 1 was verified by co-chromatography with an authentic reference standard and also comparison of the mass spectra and proton nuclear magnetic resonance (NMR) spectra of Unknown 1 and a synthetic reference standard.
Applicant's summary and conclusion
Validity criteria
- Validity criteria fulfilled:
- yes
- Conclusions:
- After 15 days of continuous exposure, degradation rates in the exposed samples were approximately two-fold greater than in the dark controls.
- Executive summary:
The photodegradation of [pheny1-14c(U)] DPX-F6025 and [pyrimidine-2-14c] DPX-F6025 (ethyl 2-[[[[4-chloro- 6-methoxypyrimidine-2-yl)amino]carbonyl]amino]sulfonyl]benzoate) was examined in sterilized, buffered, aqueous solutions at pH 5, 7, and 9. The rate of degradation of DPX-F6025 in samples exposed to simulated sunlight was compared to degradation of control samples kept protected from light. The temperature of all test solutions was maintained at 25°C.
After 15 days of continuous exposure, test substance degradation rates in the exposed samples were approximately two-fold greater than in the dark controls. At pH 5, where significant hydrolysis of the test substance occurs, the first half-life was approximately 12 days for the exposed samples compared to 29 days for the dark controls. At pH 7, the test substance degraded with a first half-life of 27 days in the irradiated samples: because of the stability of the test substance at pH 7, the half-life for the dark controls could not be calculated. At pH 9, the most hydrolytically stable pH for the test substance, the parent degraded with a first half-life of 31-43 days of continuous exposure: as for pH 7, the half-life for the dark controls could not be determined. At least four unidentified photoproducts were formed at pH 9, the largest accounting for only about 12% of the total radiolabel after 15 days of continuous high intensity exposure; ca. 70% of the original test substance remained at the end of this exposure period. Therefore, under the conditions of these studies, although photolysis does occur, it does not appear to play a major role in the degradation of the test substance.
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