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EC number: 281-865-3 | CAS number: 84045-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- other: CIBA Method A-11
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- yes
- Details on sampling:
- None
- Vehicle:
- yes
- Details on test solutions:
- Water
- Test organisms (species):
- other: trout and goldorfe
- Details on test organisms:
- None
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- None
- Post exposure observation period:
- None
- Hardness:
- None
- Test temperature:
- None
- pH:
- None
- Dissolved oxygen:
- None
- Salinity:
- None
- Conductivity:
- None
- Nominal and measured concentrations:
- None
- Details on test conditions:
- None
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Remarks:
- TL0
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks:
- trout
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Remarks:
- TL0
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks:
- goldorfe
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Remarks:
- TL50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Remarks:
- TL100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- None
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 (TL) of FAT 40000 in this fish acute toxicity test was determined to be greater than 1000 mg/L.
- Executive summary:
An acute fish toxicity test was performed with trout and goldorfe. Groups of fish were exposed at the test concentrationsof 100, 200 and 1000 mg/L. Based on the findings, the LC0 value was 200 mg/l (trout) or 1000 mg/l (goldorfe), whereas LC50 and LC100 value was determined to be greater than 1000 mg/l in both species.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- other: CIBA Method A-11
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- yes
- Details on sampling:
- None
- Vehicle:
- yes
- Details on test solutions:
- Water
- Test organisms (species):
- Salmo sp.
- Details on test organisms:
- None
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- None
- Post exposure observation period:
- None
- Hardness:
- None
- Test temperature:
- 12 °C
- pH:
- 8
- Dissolved oxygen:
- None
- Salinity:
- None
- Conductivity:
- None
- Nominal and measured concentrations:
- 100, 200 and 1000 mg/l
- Details on test conditions:
- None
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Remarks:
- TL0
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Remarks:
- TL50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Remarks:
- TL100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- None
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 (TL) of FAT 40000/A in this fish acute toxicity test was determined to be greater than 1000 mg/L.
- Executive summary:
An acute fish toxicity test was performed with trout. Groups of fish were exposed at the test concentrationsof 100, 200 and 1000 mg/L. Based on the findings, the LC0, LC50 and LC100 (TL) value was determined to be greater than 1000 mg/l.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- other: CIBA Method A-11
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- yes
- Details on sampling:
- None
- Vehicle:
- yes
- Details on test solutions:
- Water
- Test organisms (species):
- other: Red killi and trout
- Details on test organisms:
- None
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- None
- Post exposure observation period:
- None
- Hardness:
- None
- Test temperature:
- None
- pH:
- None
- Dissolved oxygen:
- None
- Salinity:
- None
- Conductivity:
- None
- Nominal and measured concentrations:
- None
- Details on test conditions:
- None
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Remarks:
- TL0
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Remarks:
- TL50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Remarks:
- TL100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- None
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 (TL) of FAT 40000/C in this fish acute toxicity test was determined to be greater than 1000 mg/L.
- Executive summary:
An acute fish toxicity test was performed with Red killi fish and trout. Based on the findings, the LC0, LC50 and LC100 (TL) value was determined to be greater than 1000 mg/l for both fish species.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- other: CIBA Method A-11
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- yes
- Details on sampling:
- None
- Vehicle:
- yes
- Details on test solutions:
- Water
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- None
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- None
- Post exposure observation period:
- None
- Hardness:
- None
- Test temperature:
- 25 °C
- pH:
- 10
- Dissolved oxygen:
- None
- Salinity:
- None
- Conductivity:
- None
- Nominal and measured concentrations:
- 300 and 1000 mg/l
- Details on test conditions:
- None
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- None
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 of FAT 40000/D in this fish acute toxicity test was determined to be greater than 1000 mg/L.
- Executive summary:
An acute fish toxicity test was performed with Zebra-fish ( Brachydanio rerio ). Groups of fish were exposed at the test concentrationsof 300 and 1000 mg/L. Based on the findings, the LC0, LC50 and LC100 value was determined to be greater than 1000 mg/l.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- other: CIBA Method A-11
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- yes
- Details on sampling:
- None
- Vehicle:
- yes
- Details on test solutions:
- Water
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- None
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- None
- Post exposure observation period:
- None
- Hardness:
- None
- Test temperature:
- 23 °C
- pH:
- 10
- Dissolved oxygen:
- None
- Salinity:
- None
- Conductivity:
- None
- Nominal and measured concentrations:
- 300 and 1000 mg/l
- Details on test conditions:
- None
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 300 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- None
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 of FAT 40000/E in this fish acute toxicity test was determined to be greater than 1000 mg/L.
- Executive summary:
An acute fish toxicity test was performed with Zebra-fish (Brachydanio rerio). Groups of fish were exposed at the test concentrationsof 300 and 1000 mg/L. Based on the findings, the LC0 value was determined to be 300 mg/l. The LC50 and LC100 value was determined to be greater than 1000 mg/l.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that the source and the target substance have very similar physicochemical and (eco)toxicological properties because their chemical structures are nearly identical. An analogue approach has thus been employed. The target substance is the meta-isomer of the dye Reactive Yellow 095, where the sulphonate group is bound at the meta-position of the amino benzene moiety. The source chemical is the reaction mass of both the meta-isomer and the para-isomer of Reactive Yellow 095.
The presence of sulphonate groups make both dyes highly water soluble and therefore less critical for human health and environmental issues. Based on their chemical similarity, similar properties are expected in both humans and the environment.
2. SOURCE AND TARGET CHEMICAL(S)
Source: Reactive Yellow 095 meta/para (CAS# --- / EC# 944-218-2)
Target: Reactive Yellow 095 meta (CAS# 84045-63-6 / EC# 281-865-3)
3. ANALOGUE APPROACH JUSTIFICATION
see attachment under 4.12 Auto flammability - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 96h-LC50 in zebrafish was >1000 mg/L.
- Executive summary:
Based on one key study and four supporting studies for the source substance, it was clear that the 96h-LC50 in fish was >1000 mg/L. The structurally related target substance will show the same behaviour, and the 96h-LC50 will be as well >1000 mg/L.
Referenceopen allclose all
Description of key information
The LC50 in fish was determined to be greater than 1000 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
A key study to determine acute toxicity to fish was performed with Zebra-fish (Brachydanio rerio). Groups of fish were exposed at the test concentrations of 300 and 1000 mg/L. Based on the findings, the LC0 values was 300 mg/L, whereas LC50 and LC100 value was determined to be greater than 1000 mg/L. Several supporting studies conducted on different batches of this test substance and involving different fish species confirmed this test result indicating that the effects are not dependent on fish species or production batch.
The structurally related target substance will show the same behaviour and therefore it can be anticipated that the 96h-LC50 in fish will be >1000 mg/L as well.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.