Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 611-646-3 | CAS number: 58374-69-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented report of a guideline study conducted to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-acrylamido-2-methylpropanesulfonic acid
- IUPAC Name:
- 2-acrylamido-2-methylpropanesulfonic acid
- Reference substance name:
- ammonium (1Z)-N-(2-methyl-1-sulfopropan-2-yl)prop-2-enimidate
- EC Number:
- 611-646-3
- Cas Number:
- 58374-69-9
- Molecular formula:
- C7H12NO4S.H4N
- IUPAC Name:
- ammonium (1Z)-N-(2-methyl-1-sulfopropan-2-yl)prop-2-enimidate
- Details on test material:
- - Name of test material (as cited in study report): OS 114454
- Substance type: organic
- Physical state: very pale brown clear liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: 50%
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: stable
- Storage condition of test material: oom temperature
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 200 mg/l
- Sampling method: no data
- Sample storage conditions before analysis: no data
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead minnow
- Strain:
- Source: Neil Hardy Aquatica Carshalton, UK,
- Age at study initiation (mean and range, SD): juvenile
- Length at study initiation: 3.8 cm (SD 0.4)
- Weight at study initiation: 0.54 g (SD 0.12)
- Feeding during test: no
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions: same as test
- Type and amount of food: Tetramin flake food
- Feeding frequency: no data
- Health during acclimation: 3% mortality in 7 days prior to test
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No
Test conditions
- Hardness:
- 100 mgll as CaC03
- Test temperature:
- 21±1°C
- Dissolved oxygen:
- >7.6 mg O2/l
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal: 200, 360, 640, 1120 and 2000 mg/l
Measured: 200, 367, 648, 1133 and 2066 mg/l at study initiation - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass
- Type: closed
- Fill volume: 20 l
- Aeration: yes
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechloinated laboratory tap water
- Total organic carbon: 1 mg/l
- Particulate matter: no data
- Metals: all below the prescribed concentration
- Pesticides: <0.08 µg/l (all below the prescribed concentration)
- Chlorine: 0.22 mg/l
- Alkalinity: 80 mg/l
- Ca/mg ratio: 5:1
- Conductivity: 382 MICSM
- Intervals of water quality measurement: initially and every 24 hours for temerature, pH and dissolved oxygen
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16 hours light/8 hours darkness
- Light intensity: no data
EFFECT PARAMETERS MEASURED: mortality and behavioural effects
TEST CONCENTRATIONS
- Spacing factor for test concentrations: no data
- Justification for using less concentrations than requested by guideline: based on range-finding study
- Range finding study
- Test concentrations: 200 and 2000 mg/l
- Results used to determine the conditions for the definitive study: yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 640 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- other: mortality and behaviour
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 400 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 1300-1600 mg/l
- Details on results:
- - Behavioural abnormalities: yes, loss of equilibrium at concentrations greater than 640 mg/l
- Observations on body length and weight: no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: none
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute LC50 at 96 hours exposure of the test article to the freshwater fish Fathead Minnow (Pimephales promelas) was determined to be1400 mg/l with 95% confidence limits of 1300-1600 mg/l. The No Observed Effect Concentration (NOEC) was 640 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.