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Diss Factsheets
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EC number: 211-525-1 | CAS number: 658-79-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 17 July 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Triplicate samples (3 x 2 x ~5 mL) were taken at the beginning and at the end of the renewal periods. Samples from the control were taken at the start and end of the renewal periods (1 x 2 x ~5 mL).
Sampled test item solutions were stored in a freezer until measurement. - Vehicle:
- no
- Details on test solutions:
- A stock solution with a concentration of 100.0 mg anhydrous form of test item/L was prepared with direct addition of the test item, mixed into aquarium water using ultrasonic bath (approximately 30 seconds), then distributed into the appropriate test flasks. As a Limit test was carried out, further dilution of stock solution was not performed.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish (Brachydanio rerio)
- Source: Hungarian University of Agriculture and Life Sciences, Department of Aquaculture 2100 Gödöllő, Páter Károly u. 1., Hungary
- Length at study initiation (length definition, mean, range and SD): 1.7 – 2.3 cm
- Weight at study initiation (mean and range, SD): control: Measured weight of 7 fish (g) => 1.14g; Calculated mean weight of 1 fish (g) => 0.16g; test item: Measured weight of 7 fish (g) => 0.9g; Calculated mean weight of 1 fish (g) => 0.13g
- Method of breeding: Fish were bred in a standard commercial fish farm, under disease- and parasite-controlled conditions.
ACCLIMATION
- Acclimation period: >12d - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 171 mg CaCO3/L
- Test temperature:
- 19.4 - 21.5°C
- pH:
- 7.74 - 8.27
- Dissolved oxygen:
- 66 - 100 %
- Nominal and measured concentrations:
- nominal: 100 mg/l
measured geometric mean: 94.2 mg/l - Details on test conditions:
- TEST SYSTEM
- Renewal rate of test solution (frequency/flow rate): 24h renewal period
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.23 g fish/litre testing liquid in the control ; 0.18 g fish/litre testing liquid in the test item group
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light (artificial illumination) and 8 hours darkness
TEST CONCENTRATIONS
Range finding study
- Test concentrations: 0.1, 1, 10, 100 mg N-Glycyl-L-tyrosine/l
- Results used to determine the conditions for the definitive study: yes => limit test - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 115 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
no
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of this acute fish toxicity study on Zebrafish (Brachydanio rerio) the observed LC50 for the test item N-Glycyl-L-tyrosine dihydrate was > 115 mg/L (nominal) corresponding to a LC50 for the active ingredient N-Glycyl-L-tyrosine of > 100 mg/L (nominal).
Reference
Description of key information
LC50 (96 h): >100 mg/L (nominal, OECD203)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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