Registration Dossier
Registration Dossier
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EC number: 204-198-1 | CAS number: 117-57-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 20 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 200 mg/L
- Incubation duration:
- >= 6 - <= 24 h
- Temp.:
- 20 °C
- pH:
- 4.8
- Remarks on result:
- other:
- Remarks:
- In a preliminary test the concentration found was 39.5 mg/L. Therefore the concentration for the main test was set to 200 mg/L. This corresponds to 5 times the concentration found in the pretest.
- Conclusions:
- In a test according to OECD 105 the water solubility of 3-Hydroxy-2-methyl-4-quinolinecarboxylic acid at 20 °C was determined to be 20 mg/L (0.020 g/L) at 20°C. Due to the acidic nature of the substance the underlying pH value was 4.8.
- Executive summary:
The water solubility of the test item 3-Hydroxy-2-methyl-4-quinolinecarboxylic acid in demineralized water was determined with the shake flask method at 20 °C according to OECD 105 and OPPTS 830.7840.
The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with DAD detection.
The relative standard deviation between the single determinations is < 15 %.
The validity criteria have therefore been met.
Water solubility of 3-Hydroxy-2-methyl-4-quinolinecarboxylic acid at 20 °C: 20 mg/L (0.020 g/L)
Reference
Results of single determinations and mean value:
| Water solubility test at 20 °C | Flask A [g/L] | Flask B [g/L] | Flask C [g/L] | Mean value [g/L] |
| Concentration of 3-Hydroxy-2-methyl-4-quinolinecarboxylic acid (Test 1) | 0.01891 |
0.02203 |
0.01928 |
0.020 |
pH-value (Test 1) |
4.8 |
4.8 |
4.8 |
4.8 |
Concentration of 3-Hydroxy-2-methyl-4-quinolinecarboxylic acid (Test 2) |
0.01792 |
0.02156 |
0.01985 |
0.020 |
pH-value (Test 2) |
4.8 |
4.8 |
4.8 |
4.8 |
Description of key information
The water solubility is 20 mg/L at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 20 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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