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EC number: 241-789-3 | CAS number: 17831-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An oral acute toxicity study is available on Tetraethylene Glycol Diacrylate in rats and shows a LD50 of 641 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June / July 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 5 female and 5 male rats were treated with the test item for one oral administration (gavage) et the doses of 316; 464, 681 and 1000 mg/kg bw. The item was dissoved in water.
The animals were checked every day during 14 days after administration. At the end of the study, the animals were weighed and necropsied. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Details on test animals or test system and environmental conditions:
- - Fasting period before study: yes 15h-20h before administration
-diet : HERILAN MRH-HALTUNG;H.EGGERSMANN KG - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Administration volume : 10 ml/kg
- Doses:
- 100, 681, 464, 316 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 641 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 516 - < 832
- Mortality:
- -At 1000 mg/kg : males = 4/5 died (at Day 1 after administration) ; females = 4/5 died (at Day 1 after administration) ; total : 8/10
-At 681 mg/kg : males = 4/5 (3 rats at day 1, 1 rat at day 7) ; females = 2/5 died (at Day 1 after administration) ; total : 6/10
-At 464 mg/kg : males = 1/5 (at day 1) ; females = 2/5 died (at Day 7 after administration) ; total : 3/10
-At 316 mg/kg : males = 0/5 ; females = 0/5 - Clinical signs:
- other: -At 1000 mg/kg : dyspnea, apathie, coarse fur -At 681 mg/kg : dyspnea, apathie, coarse fur -At 464 mg/kg : dyspnea, apathie, anemia, coarse fur -At 316 mg/kg : dyspnea, apathie
- Gross pathology:
- Died animal : Heart: Right of acute dilation; Stomach: liquid content, gastric mucosa glandular very red (haemorrhagic gastritis); Thorax / abdomen: liquid; Liver
Alive animal : Adhesions of the premature with liver and peritoneum, fliverticle formation - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the data, the oral DL50 of the test article is 641 mg/kg in rats.
- Executive summary:
5 female and 5 male rats were treated with the test item for one oral administration (gavage) et the doses of 316; 464, 681 and 1000 mg/kg bw. The item was dissoved in water.
The animals were checked every day during 14 days after administration. At the end of the study, the animals were weighed and necropsied.
Mortalities were observed at the doses of 464 mg/kg (3/10), 681 mg/kg (6/10) and 1000 mg/kg (8/10). Some clinical signs were observed in all treated animals ( dyspnea, apathie).
No changes of bodyweight were observed. Some macroscopic effects were observed at the necropsy on liver, stomach, abdomen.
Based on the data, the oral DL50 of the test article is 641 mg/kg in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 641 mg/kg bw
- Quality of whole database:
- The study is considered to be reliable with a klimisch score of 2.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral acute toxicity study (1979) :
5 female and 5 male rats were treated with the test item for one oral administration (gavage) et the doses of 316; 464, 681 and 1000 mg/kg bw. The item was dissoved in water.
The animals were checked every day during 14 days after administration. At the end of the study, the animals were weighed and necropsied.
Mortalities were observed at the doses of 464 mg/kg (3/10), 681 mg/kg (6/10) and 1000 mg/kg (8/10). Some clinical signs were observed in all treated animals ( dyspnea, apathie).
No changes of bodyweight were observed. Some macroscopic effects were observed at the necropsy on liver, stomach, abdomen.
Based on the data, the oral DL50 of the test article is 641 mg/kg in rats.
Justification for classification or non-classification
Based on the available data, a classification of tetraethyleneglycol diacrylate is required for acute toxicity according to the Regulation EC n°1272/2008 : Harmful if swallowed (Acute tox 4, H302).
Justification: the oral LD50 is between 300 and 2000 mg/kg bw.
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