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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Results of available in vitro studies:
- AMES test: negative.
- Micronucleus test in human lymphocytes: negative.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
No study available.
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The genetic toxicity of the multi-constituent substance " Reaction mass of dodecane-1-thiol and tridodecyl trithiophosphite" was investigated with different types of in vitro tests:
- AMES test: the test item was examined for the ability to induce gene mutations in tester strains of Salmonella typhimurium and Escherichia coli. The five tester strains TA1535, TA1537, TA98, TA100 and WP2 uvrA were used. Experiments were performed both in the absence and presence of S9 metabolic activation, at the following concentrations: 5.0, 2.50, 1.25, 0.625 and 0.313 µl/plate. No increases in revertant numbers were observed, at any dose level, with any tester strain, in the absence or presence of S9 metabolic activation.
- In Vitro Mammalian Cell Micronucleus according to OECD TG 487: the test item was assayed for the ability to induce micronuclei in human lymphocytes, following in vitro treatment in the presence and absence of S9 metabolic activation. Three treatment series were included in the study. A short term treatment, where the cells were treated for 3 hours, was performed in the absence and presence of S9 metabolism. The harvest time of 32 hours, corresponding to approximately two cell cycle lenghts, was used. A long term (continuous) treatment was also performed only in the absence of S9 metabolism, until harvest at approximately 31 hours.
Dose levels were selected for the scoring of micronuclei on the basis of the cytotoxicity of the test item treatments calculated by the cytokinesis-block proliferation index (CBPI). Dose levels for scoring were selected as follows:
- short-term treatment (with and without S9): 2.00, 1.33 and 0.889 μl/ml
- long-term treatment (without S9): 1.00, 0.667 and 0.444 μl/ml.
Following treatment with the test item, no statistically significant increase in the incidence of micronucleated cells over the control value was observed at any dose level, in any treatment series. It is concluded that the test item does not induce micronuclei in human lymphocytes after in vitro treatment,under the reported experimental conditions.
Justification for classification or non-classification
Reaction mass of dodecane-1-thiol and tridodecyl trithiophosphite is not classified for genetic toxicity according to the CLP Regulation (EC.n.1272/2008). For justification see the results of available studies.
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