Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 298-995-1 | CAS number: 93841-25-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In a dermal absorption study performed according to OECD guideline 428, the absorbed dose or the amount that had penetrated through the skin (receptor fluid and receptor rinse) was 0.13% (0.58 ug equiv/cm2) of the applied dose under oxidative conditions. The dermal bioavailability of hydroxyethyl-p-phenylenediamine sulfate was 0.57% (2.46 ug equiv/cm2) under oxidative conditions. The absorbed dose or the amount that had penetrated through the skin (receptor fluid and receptor rinse) was 0.16% (0.70 ug equiv/cm2) of the applied dose under non-oxidative conditions. The dermal bioavailability of hydroxyethyl-p-phenylenediamine sulfate was 0.49% (2.12 ug/cm2) under non-oxidative conditions.
The absorption, distribution and excretion of hydroxyethyl-p-phenylenediamine sulfate was studied in an in vivo study after dermal and oral administration. 14C labelled 2,5 -diaminophenylethanol sulphate (hydroxyethyl-p-phenylenediamine sulfate) was applied to the dorsal skin of rats for 30 minutes then washed off. The test substance was integrated into two different hair dyeing formulations (I and II) or was evaluated as a solution in water. Hair dyeing formulation II was mixed with Welloxon (containing 9% hydrogen peroxide) before application. Oral application of the test substance was used as a reference. An additional experiment was performed to determine the blood level after peroral application.
The mean percutaneous absorptions of the test substance were very low in each of the three experiments. (0.063% for hair dyeing formulation I, 0.077% for hair dyeing formulation II plus hydrogen peroxide, 0.124% for the test substance solution). The 14C labelled compound was excreted to a larger extent via urine (75-86% of the eliminated 14C) and to a lesser extent via faeces (14-25%). The mean excretion within the first 24 hours was fast (87-95% of the eliminated 14C in experiments A to C). Mean 14C concentrations of blood and the 14 analysed organs in experiments A to C were all near or below the detection limit after 72 hours. After oral administration of the test substance the 14C labelled compound was excreted to a larger extent via urine (86% of the eliminated 14C) and to a lesser extent via faeces (14%). The 14C compound excreted within the first 24 hours equated to 99%. Highest 14C cncentrations were detected in the thyroid, liver and adrenals. Lowest detected in testes, fat, femur. The blood level was highest after 35 minutes post administration and declined with an initial half-life of ~50 minutes.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - dermal (%):
- 0.16
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.