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EC number: 293-106-3 | CAS number: 91051-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1983
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The Skin test was carried out as a patch test.
The chosen test site was inside of the forearm and the chosen test plasters were numbers 1000 and 1500 from the Beiersdorf Company, Hamburg.
The preparation to be tested was introduced at 50% diluted in olive oil (approx 1,0g) into the chamber of the plaster; this was fixed to the skin and removed after approx. 24 hours for assessment of the result.
The following observations were made in this assessment: Marking of the individual test sites - observation and evaluation, exclusion of reflex erythema.
The assessment was repeated after 24 hours on each subject. - GLP compliance:
- no
Test material
- Reference substance name:
- Fatty acids, safflower-oil, Et esters
- EC Number:
- 293-106-3
- EC Name:
- Fatty acids, safflower-oil, Et esters
- Cas Number:
- 91051-53-5
- IUPAC Name:
- Fatty acids, safflower-oil, Et esters
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Safester A 75, 50% in Olive oil
Batch: 211088
Test animals
- Species:
- other: Humans
- Details on test animals or test system and environmental conditions:
- 50 subjects, comprising both women and men, were tested; all were in the age group between 16 and 60.
The skin region examined was the inside of the forearm in all cases.
Test system
- Amount / concentration applied:
- 1g
- Duration of treatment / exposure:
- 24h
- Observation period:
- 48h
- Number of animals:
- 50 subjects (women & men)
- Details on study design:
- The Skin test was carried out as patch test.
The chosen test site was inside of the forearm and the chosen test plasters were numbers 1000 and 1500 from the Beiersdorf Company, Hamburg.
The preparation to be tested was introduced undiluted (approx 1,0g) into the chamber of the plaster; this was fixed to the skin and removed after approx. 24 hours for assessment of the result.
The following observations were made in this assessment: Marking of the individual test sites - observation and evaluation, exclusion of reflex erythema.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: erythema dubiosum, erythema; erythema papulovesicularis; erythema papulovesicularis gravis; bulla, erosio, ulcus
- Basis:
- other: 54 persons
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- other: 54 persons
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: N/A
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- other: 54 persons
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: N/A
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: erythema dubiosum, erythema, erythema paulovesicularis; erythema
- Basis:
- other: 54 persons
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- other: 54 persons
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: N/A
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- other: 54 persons
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: N/A
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- other: 54 persons
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- other: 54 persons
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- other: erythema dubiosum, erythema, erythema paulovesicularis; erythema
- Basis:
- other: 54 persons
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- In this skin test, 54 subjects of different skin types and different degrees of sensitivity were examined. A third of the subjects had very sensitive skin prone to dermatosis and eczema.
The preparation (SAFESTER A 75, 50% in Olive oil) examined showed no reaction.
This preparation has an excellent skin tolerance.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- SAFESTER A 75 shows excellent skin compatibility and was shown to be non-irritating to the skin of human volunteers.
- Executive summary:
SAFESTER A 75 shows excellent skin compatibility and was shown to be non-irritating to the skin of human volunteers.
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