Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-516-7 | CAS number: 72243-90-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- pre GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Acid Violet 048
- IUPAC Name:
- Acid Violet 048
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 232 to 268 g
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: on the day prior to treatment, hair was removed from the dorso-lumbar region of each rat with electric clippers. No shaving or chemical depilation was used.
- % coverage: an area equivalent to 10 % of the total body surface.
- Type of wrap if used: the treated area was then promptly covered with aluminium foil which was held in place with "Sleek" waterproof plaster encircled firmly round the trunk.
REMOVAL OF TEST SUBSTANCE
- Washing: treated area of skin was decontaminated by washing with warm (40 - 50 °C) dilute soop solution, rinsing in clean warm water and finally blotting dry with absorbent paper.
- Time after start of exposure: 24 hours.
TEST MATERIAL
- Test solution: test item was prepared as a 50 % aqueous solution.
- Dosage volume: 10 ml/kg body weight. - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Ten males
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations: the areas of treated skin were examined daily for signs of local irritation. Any irritation was recorded numerically.
- Necropsy of survivors performed: all rats were sacrificed and examined macroscopically in an attempt to identify any target organs.
SCORING SYSTEM for IRRITATION
Erythema and eschar formation:
No eryrhema 0
Slight erythema 1
Well-defined erythema 2
Moderate erythema 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth) 4
Oedema formation:
No oedema 0
Slight oedema 1
Well-defined oedema (area well defined by definite raising) 2
Moderate oedema (raised approximately 1 millimeter) 3
Severe oedema (raised more than 1 millimeter and extending beyond the area of exposure) 4
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: Signs of reaction to treatment consisted of slight lethargy only. No signs of irritation to the skin were seen during the fourteen days observation period. Recovery of all animals, as iudged by external appearance and behaviour, was apparently complete wi
- Gross pathology:
- Autopsy findings were normal.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- LD50 (male) > 5000 mg/kg bw
- Executive summary:
The study was performed to assess the acute dermal toxicity of the test material in CFY rats. The test item was prepared as a 50 % aqueous solution and speaded over the prepared skin. The dose applied was 5000 mg/kg bw. On the day prior to treatment, hair was removed from the dorso-lumbar region of each rat with electric clippers; no shaving or chemical depilation was used. The treated area was then occlusively covered. Animals were observed over a period of 14 days after test item application.
No deaths occurred. Signs of reaction to treatment consisted of slight lethargy only. No signs of irritation to the skin were seen during the fourteen days observation period. Recovery of all animals, as iudged by external appearance and behaviour, was apparently complete within twenty-four hours of treatment. The bodyweight increases of the treated animals resulted to be normal compared with controls. Autopsy findings were normal.
Conlcusion
LD50 (male) > 5000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.