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EC number: 235-527-7 | CAS number: 12262-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adequate details; non-GLP; no COA; no analytical data but test atmospher analyzed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexanone, peroxide
- EC Number:
- 235-527-7
- EC Name:
- Cyclohexanone, peroxide
- Cas Number:
- 12262-58-7
- Molecular formula:
- Multi-constituent substance (equilibrium mixture of a number of cyclohexyl based organic peroxides, hydrogen peroxide, cyclohexanone and water)
- IUPAC Name:
- Peroxycyclohexanone
- Reference substance name:
- 12262-548-7
- IUPAC Name:
- 12262-548-7
- Reference substance name:
- Cyclonox LE
- IUPAC Name:
- Cyclonox LE
- Test material form:
- other: Colorless liquid
- Details on test material:
- 21% cyclohexanone peroxides
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino rats (SPF· reared, Wistar-derived) were used as the experimental animals. The weight of the males was 195-205 g, that of the females 135-145 g. The rats were obtained from the Central Institute for the Breeding of Laboratory Animals. TNO, Zeist, The Netherlands.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: Filtered air
- Details on inhalation exposure:
- The exposure chamber used consisted of a horizontally placed-glass cylinder (0.90 x 0.15 m) with sampling ports on both ends and containing stainless steel wire screens for separately accommodating the experimental animals.
Analysis of cyclohexanone peroxides, was carried out according to a
method comprising absorption in xylene followed by spectrophoto-
metrical measurement.
The dynamic atmosphere was generated by passing a known amount of
filtered air (relative humidity c.~ 45%) from the compressed air line
through five glass evaporators (1.0 l/min/evaporator). Each evaporator
was laden with Chromosorb W-AW 60/80, saturrated with Cyclonox LE-50.
The temperature of the evaporators during the experiment was 22 deg C. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- The maximum attainable concentration of the peroxide vapours in the test atmosphere was 5.0 ppm.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- One group of five males and five females was used. After exposure (4 hours), the animals were returned to their living cages and provided with stock diet and tap water ad libitum for an observation period of 14 days.
- Statistics:
- No applicable.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 ppm
- Exp. duration:
- 4 h
- Mortality:
- There were no mortalities
- Clinical signs:
- other: During the first five minutes of exposure the rats were slightly restless. However, this symptom gradually disappeared and after a quarter of an hour all rats were quiet and asleep. This situation continued thoughout the remainder of the exposure period.
- Body weight:
- No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- From the results of the present acute inhalation study it is concluded that the 4-hour LC50 of, Cyclonox LE-50 is higher than 5.0 ppm (>29 mg/m3). The study is not suitable for C&L. Only one concentraton was tested and the test atmosphere was based on the maximum attainable concentration by evaporation at 22 degrees celcius.
- Executive summary:
The acute inhalation toxicity of Cyclonox LE-50 was studied by exposing rats for four hours to the vapour of this substance at the highest concentration attainable.
At 5.0 ppm; which is the highest peroxide concentration possible under the experimental conditions, no mortality or signs of intoxication were observed.
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