Registration Dossier
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EC number: 203-367-7 | CAS number: 106-15-0
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test compound 12-hydroxy-N-(2-hydroxyethyl) octadecan-1-amide (CAS no. 106 -15 -0) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 12-hydroxy-N-(2-hydroxyethyl)octadecan-1-amide is expected to be readily biodegradable.
Biodegradation in water and sediment
Estimation Programs Interface (2018) prediction model was run to predict the half-life in water and sediment for the test chemical. If released in to the environment, 21.9% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.545%), indicates that test chemical is not persistent in sediment.
Biodegradation in soil
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (2018). If released into the environment, 77.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Predicted data study for target chemical 12-hydroxy-N-(2-hydroxyethyl)octadecan-1-amide (CAS no. 106 -15 -0) and experimental studies for its structurally and functionally similar read across chemicals have been conducted and their results are summarized below.
In first predicted data study the Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test compound 12-hydroxy-N-(2-hydroxyethyl)octadecan-1-amide (CAS no. 106 -15 -0) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 12-hydroxy-N-(2-hydroxyethyl)octadecan-1-amide is expected to be readily biodegradable.
In an another study. the test chemical was subjected to biodegradation test by taking activated sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using two parameters namely BOD and GC. The initial concentration of test chemical was 100 mg/L.The test chemical showed 52 % biodegradability by BOD parameter and 73 % by GC parameter by using activated sludge as inoculumin 28 days. On the basis of percent biodegradability it is concluded that test chemical is readily biodegradable.
By considering results of all the studies mentioned above it can be concluded that test chemical 12-hydroxy-N-(2-hydroxyethyl)octadecan-1-amide (CAS no. 106 -15 -0) is expected to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (2018) prediction model was run to predict the half-life in water and sediment for the test chemical. If released in to the environment, 21.9% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.545%), indicates that test chemical is not persistent in sediment.
Biodegradation in soil
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (2018). If released into the environment, 77.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
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