Registration Dossier
Registration Dossier
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EC number: 231-726-8 | CAS number: 7704-98-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
- Objective of study:
- distribution
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Refer to the full paper in material and methods section.
The objective of the study was to compare the effects of intravenous and oral administration of metal on the organism (male albino Wistar rats). - GLP compliance:
- no
Test material
- Specific details on test material used for the study:
- Titanium(IV) citrate (C18H12NaO21Ti-7)
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The study made by the team of Golasik (2016) shows that titanium in ionic form has low oral bioavailability (3.8%) and is poorly absorbed into the circulation.
The Ti concentration 3 h after intravenous administration was about 100 times higher in serum, 10 times higher in kidneys and spleen, 8 times higher in liver than after the same time following 30-days repeated intragastric administration. The main organ for titanium deposition after administration of a soluble salt is kidney. This result might be related to the role of the kidneys with the elimination of this form of metal. The present results suggest that the exposure to ionic titanium should not result in excessive accumulation of metal in the organism.
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