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Diss Factsheets
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EC number: 947-152-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974 (no details)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
similar to standard test methods. Groups of 6 males were exposed to a gaseous atmosphere of the test substance at 5 different concentrations.
- Short description of test conditions: 4 hour exposure followed by a 14-day post-exposure period.
- Parameters analysed / observed: lethality, clinical signs, gross pathology and micrscopic examination. - GLP compliance:
- not specified
- Remarks:
- Prior to GLP standards
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- Difluoro(fluorosulphonyl)acetyl fluoride
- EC Number:
- 211-642-8
- EC Name:
- Difluoro(fluorosulphonyl)acetyl fluoride
- Cas Number:
- 677-67-8
- Molecular formula:
- C2F4O3S
- IUPAC Name:
- difluoro(fluorosulfonyl)acetyl fluoride
Constituent 1
- Specific details on test material used for the study:
- fluorosulfonyl difluoroacetyl fluoride, boiling point 29°C
For the study, the test material was kept in the gaseous state (BP 29°C) by heating the cyclinder to 40°C
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 250-300 g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: not specified
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: the cylinder containing the test material was placed in an upright mutliple unit electric furnace heated to 40°C and controled by a Pyr-o-vane controller. Concentration was regulated by dual valve system. Stainless steel tubing, enveloped in heating tapes to keep the temperature above 29°C, led to the top of the exposure chamber.
- Exposure chamber volume: 20 liters
- Air flow: 2.4L/minute N2 and 0.6 L/Minute O2
- Temperature, humidity, pressure in air chamber: no data
TEST ATMOSPHERE
Test chamber air was drawn by vacuum pump into midget impingers containing 10 ml of 0.05 NaOH. Samples were read on a Beckman pH meter with a fluorine selective elctrode and compared to a standard curve (w/v) of the substance in 0.05 NaOH.
VEHICLE
- Composition of vehicle: air
- Chamber O2: 18-20%, checked with a Beckman O2 meter. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 135, 226, 272, 872, 1790 ppm (v/v)
- No. of animals per sex per dose:
- 6 males/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no details
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
- Histopathology on the following tissues: lung, trachea, bronchi, liver, kidney, testis, epididymis, thymus, thyroid, adrenal, esophagus; stomach, intestine, heart, pancreas, brain, eye, bone marrow, skin (ear). - Statistics:
- The LC50 was determined by the Litchfield-Wilcoxon method
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 220 ppm
- Based on:
- test mat.
- 95% CL:
- >= 176 - <= 275
- Exp. duration:
- 4 h
- Mortality:
- Animals exposed to the highest concentration died during the exposure period.
See details in result table. - Clinical signs:
- other: At lethal concentration: erythema, gasping, corneal opacity, hypersensitivity to touch At non-lethal concentrations: red eyes, increased respiration
- Body weight:
- The weight was recorded, but no figures provided in the report.
At high concentrations there was a moderate to severe weight loss for several days post-exposure, followed by slow weight gain. - Gross pathology:
- see result table
- Other findings:
- - Histopathology: tubular cell necrosis was observed in the animals of the high concentration, and in the surviving rat of the 272 ppm group
- Potential target organs: kidney
- Other observations: corneal opacity was reported in several animals at lethal concentrations, and in one surviving animal of the 226 ppm group.
Any other information on results incl. tables
Table 1 - results
concentration (ppm v/v) | lethality | comments |
gross pathology | histopathology |
135 | 0/6 | no unusual findings | ||
226 | 3/6 | 1 died within 72 hours, 2 died within 96 hours post-exposure | 1 of the surviving rats had bilateral corneal opacity | no unusual findings in the 3 surviving rats after 14-day post-exposure No pathological examination was performed on the 3 rats that died 5 days post exposure due to putrefied condition |
272 | 5/6 | 2 died during exposure, 2 died within 48 hours, 1 died 96 hours post-exposure | - kidney: renal tubular cell necrosis in the surviving rat | |
872 | 6/6 | 3 died during exposure, 3 died within 24 hours post-exposure | (not examined) | (not examined) |
1790 | 6/6 | died during exposure | - bilateral corneal opacity in 2 rats (out of 2 examined) - moderate subcutaneous edema in the ear skin of 2 rats (2 examined) |
- lung: intra-alveolar hemorrhage - kidney: focal cortical tubular cell necrosis - thymus: moderate to marked focal hemorrhage |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- The 4-hour acute LC50 for fluorosulfonyl difluoroacetyl fluoride was determined to be 220 ppm (v/v) in air.
- Executive summary:
Fluorosulfonyl difluoroacetyl fluoride was assessed in an acute inhalation toxicity study in rats. Five groups of 6 males were exposed for 4 hours (whole body) to increasing concentrations (135 to 1790 ppm v/v) of Fluorosulfonyl difluoroacetyl fluoride in a gaseous form to determine the LC50.
Animals were observed for mortality and clinical signs for 14-day post-exposure.
In the groups exposed to the two highest concentrations, all the animals died during the exposure period, or within 24 hours (3 animals in the 872 ppm group). At the lethal concentrations, animals displayed erythema, gasping, corneal opacity and hypersensitivity to touch, and at the non-lethal concentrations, red eyes and increased respiration.
Gross pathology examination of some of the animals of the highest concentration rats showed corneal opacity and subcutaneous edema in the ear skin.
Microscopic examination showed in the dead animals of the high concentration group intra-alveolar haemorrhage to the lung and focal haemorrhage in the thymus. Focal cortical tubular necrosis (kidney) was seen in animals of the high concentration and in the surviving animal of the group exposed to 272 ppm. All animals of the lowest concentration (135 ppm) survived with no unusual changes.
The LC50 was determined to be 220 ppm (v/v) in air. Clinical and pathological examinations showed signs of irritation and/or corrosion.
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