Registration Dossier
Registration Dossier
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EC number: 201-891-0 | CAS number: 89-25-8
Endpoint summary
Administrative data
Description of key information
The No Observed Adverse Effect Level (NOAEL) and the Low Observed Adverse Effect Level of the registered item 1-phenyl-3-methyl-5-pyrazolone (A039) was defined respectively as 20 mg/kg/day and 100 mg/kg/day according to the results of the key studies and the REACh regulation.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 20 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
Justification for classification or non-classification
The No Observed Effect Level (NOEL) and the Low Observed Adverse Effect Level of the registered item 1-phenyl-3-methyl-5-pyrazolone (A039) was defined respectively as 20 mg/kg/day and 100 mg/kg/day according to the results of the key studies (clinical signs, pathological changes of spleen, bodyweight, anemia) and the REACh regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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