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Diss Factsheets
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EC number: 210-535-3 | CAS number: 617-86-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity with triethylsilane in the rat (Crl: CD), the LD50 was >2000 mg/kg bw (OECD Guideline 401, GLP compliant, LPT 2002a).
In an inhalation toxicity whole-body vapour inhalation acute study with the surrogate substance, trimethylsilane, in the Fischer 344 rat, the LC50 after a 4 hour exposure period was greater than 1774 ppm, which is equivalent to > 5.4 mg/l, >5400 mg/m³ (OECD Guideline 403, GLP compliant, Dow Corning Corporation, 2001).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5 400 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Data are available for triethylsilane from an acute oral toxicity study. No further data are available for the registered substance, so data have been read across from an inhalation toxicity study on the structural analogue, trimethylsilane (CAS 993-07-7).
In the key acute oral toxicity study, triethylsilane was tested in a study conducted according to OECD 423 and in compliance with GLP (LPT 2002a). The test substance was administered by gavage to one group of 3 male and 3 female rats. Rats were dosed at 2000 mg/kg bw. No clinical signs of systemic toxicity were observed, no deaths occurred, and no abnormalities were found post mortem. The LD50 was determined to be >2000 mg/kg bw.
Trimethylsilane has been tested in accordance with OECD 403 and in compliance with GLP. No treatment-related effects were observed (Dow Corning Corporation, 2001). It is concluded that the whole-body inhalation LC50 value for trimethylsilane in the Fischer 344 rat is greater than 1774 ppm (5.4 mg/L, 5400 mg/m³), the highest concentration tested.
To reduce animal testing REACH recommends to make use of a read-across approach where appropriate based on the high accordance in properties relevant for the specific endpoint. In the case of acute toxicity the relevant properties are structural similarity, hydrolysis stability and the physical-chemical parameters in the same range.
Read-across hypothesis
The read across hypothesis is that triethylsilane and trimethylsilane are both hydrolytically stable at pH7 on the timescale of an acute inhalation toxicity test, and are structurally similar with similar physicochemical properties and therefore are expected to have similar toxicity profiles.
The acute dermal toxicity study on analogue substance, tetramethylsilane (CAS 75-76-3) is included in support of the read-across justification, as data for this substance are used as key data for skin sensitisation, repeated dose toxicity, genetic toxicity and toxicity to reproduction.
See Section 'Repeated dose toxicity' for further justification of the read-across.
Justification for classification or non-classification
Based on the available acute oral and inhalation toxicity data, triethylsilane does not require classification for acute toxicity according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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