Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 282-162-4 | CAS number: 84100-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
-skin irritation: not irritating; OECD 404 (12 May 1981); RL4; GLP; no effect in any animal (DRAIZE grade 0)
-eye irritation: not irritating; OECD 405 (24 Feb 1987); RL4; GLP; chemosis (DRAIZE grade 1) in one animal; fully reversible after 24 hours of application; no effect in any other animal.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988-09-13 to 1988-09-20
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 12 May 1981
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Other: beige color, pH approx. 4 (100 g/L H20)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd.
- Weight at study initiation: 2.9-3.4 kg
- Housing: individual cages (type III) stored in separate section in animal room
- Diet (e.g. ad libitum): ssniff K 4; 1 x 100-120 g/animal/day
- Water (e.g. ad libitum): tap water (7 am to 7 pm)
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2
- Humidity (%): approx. 50
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 / 12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg of moisted test substance
VEHICLE
- Amount(s) applied (volume or weight with unit): only small amounts for humidification
NEGATIVE CONTROL
- Amount(s) applied (volume or weight): only small amounts of vehicle (water only) - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 1, 24, 48, 72 hours as well as 7 day after end of exposure
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 x 6 cm
- Type of wrap if used: adhesive plaster (Hansamed - Wundpflaster Hypoallergen (Beiersdorf No. 2342)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes (water)
- Time after start of exposure: 4 hrs
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) 1, 24, 28, 72 hours as well as 7 days after end of exposure
SCORING SYSTEM:
- Method of calculation: DRAIZE-grades - Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2, #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2, #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- All animals had a score of 0.0 for both erythema and edema during the entire observation period.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Trimethylcarbonsäure was not irritating in the in vivo skin irritation test under the experimental conditions described in this report.
- Executive summary:
In a primary dermal irritation study performed in accordance with OECD Guideline 404 (Acute Dermal Irritation / Corrosion), adopted 12 May 1981, adult male albino rabbits (strain New Zealand White) were dermally exposed to 500 mg of humidified Trimethylcarbonsäure (vehicle: water) for 4 hours to 36 cm² body surface area. Animals then were observed for 7 days. Irritation was scored by the method of DRAIZE.
No irritation occurred during the observation period (DRAIZE grade 0 in all animals).
In this study, Trimethylcarbonsäure is not a dermal irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988-09-13 to 1988-09-20
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted 24 February 1987
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd.
- Weight at study initiation: 2.9-3.1 kg
- Housing: individual cages (type III) stored in separate section in animal room
- Diet (e.g. ad libitum): ssniff K 4; 1 x 100-120 g/animal/day
- Water (e.g. ad libitum): tap water (7 am to 7 pm)
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2
- Humidity (%): approx. 50
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 / 12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 µL (80 mg) - Duration of treatment / exposure:
- 24 hrs
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: physiological NaCl
- Time after start of exposure: 24 h
SCORING SYSTEM: DRAIZE; chamber water (clouding) according to MCDONALD and SHADDUCK
TOOL USED TO ASSESS SCORE: fluorescein treatment for observation of epithelial defects under UV light and white light, modified according to MCDONALD and SHADDUCK - Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1, #2, #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #2, #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritant / corrosive response data:
- Only one animal (D3) showed a swollen conjunctiva one hour after end of application. However, this effect fully reversed within 24 hours after end of application. All other animals had a DRAIZE-Grade of 0.0 in all observed organs during the entire observation period.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, Trimethylcarbonsäure showed no effects on the eyes.
- Executive summary:
In a primary eye irritation study performed in accordance with OECD Guideline 405 (Acute Eye Irritation / Corrosion), adopted 24 February 1987, Trimethylcarbonsäure was instilled into the conjunctival sac of adult male albino rabbits (strain New Zealand White) for 24 hours and washed with physiological NaCl. Animals then were observed for 7 days. Irritation was scored by the method of DRAIZE and chamber water by the method of MCDONALD and SHADDUCK.
Only in one animal chemosis (DRAIZE grade 1) was observed one hour after end of application. However, this effect fully reversed within 24 hours after end of application. Apart from this single observation, no irritation occurred in any animal during the entire observation period.
In this study, Trimethylcarbonsäure is not an eye irritant.
Reference
OTHER RESULTS OF IN VIVO STUDY
- Irritation parameter: Fluorescein
- Basis: animal: #1, #2, #3
- Time point: 24 h
- Score: 0.0
- Max. score: 4.0
- Irritation parameter: aqueous humour
- Basis: animal: #1, #2, #3
- Time point: 24/48/72 h
- Score: 0.0
- Max. score: 3.0
- Irritation parameter: Lacrimation
- Basis: animal: #1, #2, #3
- Time point: 24/48/72 h
- Score: 0.0
- Max. score: 3.0
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin irritation
Based on available and relevant data, the test substance does not need to be classified for skin irritation according to regulation (EC) 1272/2008.
Eye irritation
Based on available and relevant data, the test substance does not need to be classified for skin irritation according to regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.