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EC number: 220-076-0 | CAS number: 2623-23-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There are no data available on the aquatic toxicity ofthe target substance. In order to fulfil the standard information requirements read-across from structurally related substances was conducted in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).
Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity. Please refer to IUCLID section 13 for a detailed justification of the analogue approach.
The source substance menthyl acetate (CAS 89-48-5) was used for read-across purposes. This substance is a racemic mixture of L-menthyl acetate and D-menthyl acetate thus containing the target substance. The presence of D-menthyl acetate in the mixture is not considered to have a remarkable impact on the assessment of the aquatic toxicity of the target substance. For the structurally similar stereoisomers D- and L-menthol it was shown that their different isomeric structure has no impact on the toxicity profile as discussed and justified in the OECD SIDS report (OECD, 2003). For completeness data from the second source substance L-menthol (CAS 2216-51-5) was used for read-across as well. L-menthol is the expected abiotic hydrolysis product of the target substance L-menthyl acetate. Acetic acid as the second hydrolysis product was not used for read-across purposes since it is not expected to contribute to the overall toxicity profile of the target substance (US HPV, 2001). All ecotoxicological studies discussed in this review resulted in higher effect concentrations compared to the available studies used for read-across for L-menthyl acetate.
Experimental studies with the source substance menthyl acetate
(CAS 89-48-5) cover the toxicity to three trophic levels (fish, aquatic
invertebrates and algae). All studies were performed according to
internationally accepted guidelines and the principles of GLP. Aquatic
algae turned out to be the most sensitive species. The study resulted in
an ErC50 (72 h) of 2.7 mg/L (meas. (geom. mean) and an ErC10 (72 h) of
0.61 mg/L (meas. (geom. mean). Short-term toxicity testing with
freshwater fish resulted in a LC50 (96 h) of 6.72 mg/L (meas. (geom.
mean) followed by aquatic invertebrates with an EC50 (48 h) 9.1 mg/L
(meas. (arith. mean).The respiration of activated sludge is not
considered to be inhibited based on the result of the toxicity control
from a standard biodegradation study. No inhibition of degradation was
recorded up to a concentration of 2.6 mg/L. Thus, the NOEC (28 d) was
derived to be ≥ 2.6 mg/L.
The available studies for the second source substance L-menthol
(expected hydrolysis product) resulted in slightly higher effect
concentrations. Freshwater fish turned out to be the most sensitive
species (LC50 (96 h) 15.6 mg/L (meas. (arith. mean)) followed by aquatic
algae (ErC50 (72 h) 21.4 mg/L (meas. (arithm. mean)); NOErC (72 h) 9.65
mg/L (meas. (arithm. mean)) and aquatic invertebrates (EC50 (48 h) 26.6
mg/L (nominal)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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