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EC number: 212-094-2 | CAS number: 762-16-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study with adequate details. No COA but the test article was identified as dicotanoyl peroxide.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Dioctanoyl peroxide
- EC Number:
- 212-094-2
- EC Name:
- Dioctanoyl peroxide
- Cas Number:
- 762-16-3
- Molecular formula:
- C16H30O4
- IUPAC Name:
- octanoyl octaneperoxoate
- Test material form:
- other: solid
- Details on test material:
- Perkadox SE-8: di-octanoyl peroxide
Stored ' at -20 C until use
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- 0.5 grams
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 and 72 hours after application
- Number of animals:
- Six intact and six abraded.
- Details on study design:
- Primary irritation to the skin is measured by patch test technique
on the abraded and intact skin of albino rabbits.
Twelve healthy adult New Zealand White albino rabbits were used.
Twenty four hours prior to applying the material
the hair is removed from the backs of the animals with an electric clipper
in such away as to avoid abrasion.
An amount of 0.5 ml (in case of liquids) or 0.5 g (in case of solids
or semi-solids) of the test substance is brought on the intact or abraded
skin under a surgical patch measuring 1 inch x 1 inch; The patches are
fixed to the application site by means of adhesive tape and the entire
trunk of the rabbits is wrapped with an impervious material to maintain
the test patches in position and to retard evaporation of volatile substances.
Six rabbits are treated on the intact skin, the other six on the
abraded skin. The abrasions are are minor incisions through the stratum
corneum but not sufficiently deep to disturb the derma or to produce
bleeding.
After an exposure period of 24 hours the patches and the material
applied are removed and the resulting skin reactions are evaluated by the
method of Draize (J. Pharmacol. 82 (1944) 377 - 390). A second reading is
made 48 hours later (72 hour after application).
In the case of surface active test substances the skin reactions after
72 hours usually consist of scaliness and/or necrosis. Since the Draize
grading system does not comprise these abnormalities the second reading
is carried out on the basis of the ClVO-grading system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2.66
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2.16
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.16
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- positive indication of irritation
Any other information on results incl. tables
intact skin abraded skin
rabbit 24 hours 72 hours rabbit 24 hours 72 hours
no A B A B no A B A B
5516 3 -2 3 -1 5510 3 -2 3-1
5517 2 -2 3 -2 5511 4- 3 3 -2
5518 2 -3 3 -1 5512 3 -2 3 -1
5519 3 -2 3 -1 5513 2 -2 0 -0
5520 3 -2 3 -1 5514 3 -2 3 -1
5521 3 -2 3 -1 5515 2 -2 3 -1
aver.: 4.8 4.2 5.0 3.5
A = erythema; B = edema
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Dioctanoyl peroxide was severly irritating to rabbit skin following a 24-hour exposure.
- Executive summary:
Dioctanoyl peroxide was evaluated for skin reactions following a 24 -hour exposure on intact and abraded skin. Evaluations were made following the 24 -hour expousre and 48 hours later (72 -hours post exposure). Evaluations were based on the Draize method.
Diotanoyl peroxided was severely irritating to rabbit skin following a 24 -hour exposure.
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