Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-226-0 | CAS number: 3391-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Oct-1-ene-3-ol
- EC Number:
- 222-226-0
- EC Name:
- Oct-1-ene-3-ol
- Cas Number:
- 3391-86-4
- Molecular formula:
- C8H16O
- IUPAC Name:
- oct-1-en-3-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No. of test material: Bedoukian Research Inc.; 2005005-0019
- Expiration date of the lot/batch: December 22, 2006
- Purity test date: January 5, 2005
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: tightly sealed under inert gas in a cool, well-ventilated area
- Stability under test conditions: stable
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan, Indianapolis, Indiana, USA
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: at least 49 days old
- Weight at study initiation: 226.0-240.3 g
- Fasting period before study: night prior to dosing
- Housing: single animals in polycarbonate cages
- Diet (e.g. ad libitum): TEK 7012 Rodent Diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 68 +/-5 degrees C
- Humidity (%): 30-70%
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: April 25, 2005 To: May 17, 2005
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 0.09 mL
DOSAGE PREPARATION (if unusual): The test substance was dosed as is.
- Doses:
- The test used the up-and-down procedure. Dosages ranged from 99 mg/kg to 310 mg/kg.
- No. of animals per sex per dose:
- 6 female animals were used. As the test used the up-and-down procedure, the number of animals at each dosage varied.
At 99 mg/kg only one animal was tested.
At 175 mg/kg 3 animals were tested.
At 310 mg/kg 2 animals were tested. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross lesions, histopathology - Statistics:
- The program AOT425StatPgm was used for statistical analysis.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 175 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 87 - <= 426
- Mortality:
- The only animal dosed at 99 mg/kg survived.
One animal from the 3 animal dosed at 175 mg/kg died. (1/3)
Both animals dosed at 310 mg/kg died. (2/2) - Clinical signs:
- other: Animal 1 (175 mg/kg dose level) showed labored, slow breathing, catalepsy, and died during the first 4 hrs after dosing. Animal 2 (99 mg/kg dose level) and animal 5 (175 mg/kg level) showed piloerection. Animals 4 and 6 (310 mg/kg dose level) died within
- Other findings:
- - Histopathology: Animal 1 (175 mg/kg dose level) and animals 4 and 6 (310 mg/kg dose level) showed bright red livers and kidneys that were dark inside at the necropsy.
Any other information on results incl. tables
Animal |
Weight Change (g) |
Clinical Observations |
Necropsy Observations |
No. 1 at 175 mg/kg |
N/A |
Dyspnea, Catalepsy, Toxic Death |
Bright red liver, kidneys dark inside |
No. 2 at 99 mg/kg |
22.9 |
Piloerection |
Normal |
No. 3 at 175 mg/kg |
10.8 |
None |
Normal |
No. 4 at 310 mg/kg |
N/A |
Toxic Death |
Bright red liver, kidneys dark inside |
No. 5 at 175 mg/kg |
9.1 |
Piloerection |
Normal |
No. 6 at 310 mg/kg |
N/A |
Toxic Death |
Bright red liver, kidneys dark inside |
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral LD50 is 175 mg/kg.
- Executive summary:
The acute oral toxicity of 1-octen-3-ol was tested in an OECD Guideline 425 test using the up-and-down procedure. The first animal was dosed at 175 mg/kg. As that animal died, the second was dosed at 99 mg/kg. As the second animal survived, the third animal was dosed at 175 mg/kg. As the third animal survived, the fourth animal was dosed at 310 mg/kg. As the fourth animal died, the fifth animal was dosed at 175 mg/kg. As the fifth animal survived, the sixth animal was dosed at 310 mg/kg and then died. The LD50 was therefore determined to be 175 mg/kg with a 95% confidence limit of 87-426 mg/kg. This places the test substance in acute oral toxicity category 3 according to GHS guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.