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Diss Factsheets
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EC number: 235-166-5 | CAS number: 12108-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- environmental conditions not mentioned. Exposure was for 24 hours rater than the recommended time of 4 hours. Skin on two sides of the rabbit is tested, but one of the sides is abraded, testing was not carried out through reversibility (up to 14 days)..
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLP guidelines.
Test material
- Reference substance name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- EC Number:
- 235-166-5
- EC Name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- Cas Number:
- 12108-13-3
- Molecular formula:
- C9H7MnO3
- IUPAC Name:
- tricarbonyl(methyl-η5-cyclopentadienyl)manganese
- Details on test material:
- - Name of test material: methylcyclopentadienyl manganese tricarbonyl
- Physical state: Amber liquid
- Lot/batch No.: 548-76
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not mentioned
- Age at study initiation: Not mentioned
- Weight at study initiation: 1.9-2.3 kg
- Housing: No data
- Diet: No data
- Water : No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
Not reported.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: Two sides per rabbit were used, one abraded and other intact.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 24 hours.
- Observation period:
- 72 hours in total, with observations recorded at 24 and 72 hours.
- Number of animals:
- 6 Rabbits.
- Details on study design:
- TEST SITE
- Area of exposure: Back and sides, a site to the left of the spinal column was abraded, while a site to the right of the spinal column was left intact.
- % coverage: no data
- Type of wrap if used: Surgical gauze, each site was a 1x1 area, two layers thick.
REMOVAL OF TEST SUBSTANCE
- Washing: No
- Time after start of exposure: N.A.
SCORING SYSTEM: Erythema and eschar formation and edema formation
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.25
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Intact Skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.79
- Max. score:
- 8
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded and intact skin
- Irritant / corrosive response data:
- The raw data is presented in table 1 and table 2 on the field "Remarks on results including tables and figures".
Any other information on results incl. tables
Table 1 - Erythema and eschar formation:
|
Exposure time (Hours) |
Rabbit No. |
Mean score |
|||||
|
1 |
2 |
3 |
4 |
5 |
6 |
||
Intact skin |
24 |
2 |
1 |
1 |
2 |
1 |
1 |
1.33 |
Abraded skin |
24 |
1 |
1 |
1 |
2 |
2 |
1 |
1.33 |
Intact skin |
72 |
1 |
2 |
0 |
2 |
1 |
1 |
1.17 |
Abraded skin |
72 |
2 |
2 |
0 |
2 |
1 |
1 |
1.33 |
Table 2 - Edema formation:
|
Exposure time (Hours) |
Rabbit No. |
Mean score |
|||||
|
1 |
2 |
3 |
4 |
5 |
6 |
||
Intact skin |
24 |
2 |
2 |
2 |
2 |
2 |
2 |
2.00 |
Abraded skin |
24 |
2 |
2 |
1 |
2 |
2 |
2 |
1.83 |
Intact skin |
72 |
1 |
2 |
0 |
1 |
1 |
1 |
1.00 |
Abraded skin |
72 |
2 |
2 |
0 |
1 |
1 |
1 |
1.17 |
Total sum of mean score (erythema + edema) = 11.16
Primary Dermal Irritation Index = Sum of Mean Scores/4 = 2.79
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information mmt is not classified as a skin irritant per EC/1272/2008.
- Conclusions:
- Although the primary dermal index score for mmt was 2.79., neither the erythema/eschar score nor the edema score exceeded the score of 2.3 in any animal. This score is necessary for classification under EC/1272/2008.
- Executive summary:
In a primary dermal irritation study, six New Zealand rabbits were dermally exposed to 0.5 ml of unchanged mmt for 24 hours. Animals were then observed for 72 hours. Irritation was scored by the method of OECD grading of skin reaction.
Although the primary dermal irritation index for erythema and oedema was 2.79, neither the erythema/eschar score nor the edema score exceeded the score of 2.3 necessary for classification under EC/1272/2008.
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