Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-968-0 | CAS number: 599-64-4
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with section 7.16 of Column 2 of Annex IX, the study does not need to be conducted if it is scientifically not possible to perform the test, for instance if the analytical method is not sensitive enough.
Two studies were carried out in accordance with OECD guideline 112 using the titration method and the spectrophotometric method. Neither was successful at determining the dissociation constant therefore it is considered justified to omit the study as it is scientifically not possible to perform the test.
Key value for chemical safety assessment
Additional information
The dissociation constant for p-Cumylphenol was investigated using potentiometric titration in a GLP-compliant study performed in accordance with OECD Test Guideline 112 (Springborn Smithers Laboratories, 2009).
The pKa value of p-Cumylphenol could not be determined by potentiometric titration. Potentiometric titration of test solutions at approximately 0.090 g/L p-Cumylphenol in CO2-free water with 0.1 N sodium hydroxide failed due to precipitation of the test substance. Furthermore, potentiometric titration of test solutions at approximately 0.200 g/L in 30 % methanol with 0.01 N sodium hydroxide and 0.500 g/L p-Cumylphenol in 1.0, 10 and 30 % acetonitrile with 0.01 N and 0.1 N sodium hydroxide and 0.01 N and 0.1 N hydrochloric acid did not yield reportable results since a break in the titration curves was not observed.
The dissociation constant for p-Cumylphenol was investigated using spectrophotometric determination in a GLP-compliant study performed in accordance with OECD Test Guideline 112 (Springborn Smithers Laboratories, 2009).
The pKa could not be determined by spectrophotometric determination. Spectrophotometric determination of the 10.0 mg/L samples at pH 4, 7 and 9 did show a slight shift in the peak maximum wavelength from 197 nm to 225 nm, but there was not enough wavelength resolution or the enhancement of a peak at any other wavelength to calculate pKa.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
