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EC number: 700-012-2 | CAS number: 950919-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 22 June 2009 to 25 June 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- This study was performed according to OECD Guideline 121 and EU Method C.19 with GLP statement. This study is well documented and all validity criteria were fulfilled. No deviations were observed.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 22 January 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2009-03-04
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 30°C (Column temperature)
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC System
- Type: Agilent Technologies 1100, incorporating autosampler and workstation.
- Type, material and dimension of analytical (guard) column: Column = Phenosphere Next CN 5µ (250 x 4.6 mm id)
- Detection system: UV detector wavelength
MOBILE PHASES
- Type: Methanol:water (55:45 v/v)
- pH: 6.75
- Solutes for dissolving test and reference substances: The test item and reference standards were prepared in methanol. The dead time solution was diluted in methanol:water (55:45 v/v).
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column (formamide, purity 99.94%)
REFERENCE SUBSTANCES
- Identity: Acetanilide, Phenol, Atrazine, Isoproturon, Triadimenol, Linuron, Naphthalene, Endosulfan-diol, Fenthion, alpha-Endosulfan, Phenanthrene, Diclofop-methyl, DDT.
DETERMINATION OF RETENTION TIMES
- Quantity introduced in the column: Injection volume 10 µL; Flow rate 1.0 mL/min.
REPETITIONS
- Number of determinations: The sample, dead time and reference standard solutions were injected in duplicate.
EVALUATION
- Calculation of capacity factors k' = (tr - t0) / t0, which tr = retention time (min) and t0 = dead time (min).
- Determination of the log Koc value = (log k' - A) / B, which A = intercept of the calibration curve and B = slope of the calibration curve. - Details on sampling:
- Not applicable
- Details on matrix:
- Not applicable
- Details on test conditions:
- Not applicable
- Computational methods:
- Not applicable
- Key result
- Type:
- log Koc
- Value:
- 1.91
- Temp.:
- 30 °C
- Key result
- Type:
- Koc
- Value:
- 80.5
- Temp.:
- 30 °C
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: See table 5.4.1/1 in "Any other information on results incl. tables".
- Details of fitted regression line (log k' vs. log Koc): A = -1.063; B = 0.355; r²=0.977.
- Graph of regression line attached: Yes. See in "Illustration"
- Average retention data for test substance: See table 5.4.1/2 in "Any other information on results incl. tables".
The method guidelines require determination of adsorption coefficient on the ionised and non-ionised forms of a test material, if dissociation is possible within the environmentally relevant pH range. However, in the absence of such dissociating groups, a single determination only was performed at an approximately neutral pH, with the test material in a non-ionised form. - Adsorption and desorption constants:
- Not applicable
- Recovery of test material:
- Not applicable
- Concentration of test substance at end of adsorption equilibration period:
- Not applicable
- Concentration of test substance at end of desorption equilibration period:
- Not applicable
- Transformation products:
- not measured
- Details on results (Batch equilibrium method):
- Not applicable
- Statistics:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test substance has been determined to be 80.5 (log Koc = 1.91). The result indicates that the test item is highly mobile (according to P.J. McCall et al., 1980).
- Executive summary:
This study was performed according to OECD Guideline 121 and EU Method C.19 with GLP statement, to assess the adsorption coefficient of the test substance. The test utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
As the slope of the calibration curve for the reference standards showed good first order correlation and as the retention times between duplicate injections for the test substance was similar, the HPLC method was considered valid for the determination of adsorption coefficient. All validity criteria were fulfilled.
The adsorption coefficient (Koc) of the test substance has been determined to be 80.5 (log Koc = 1.91). The result indicates that the test item is highly mobile (according to P.J. McCall et al., 1980).
Reference
Table 5.4.1/1: The retention times of the dead time and the reference times, capacity factors and log Koc values for the reference standards
Standard |
Retention time (mins) |
Mean retention time (mins) |
Capacity factor (k') |
Log k’ |
Log Koc |
|
Injection 1 |
Injection 2 |
|||||
Formamide |
3.298 |
3.299 |
3.299 |
- |
- |
- |
Acetanilide |
4.003 |
4.003 |
4.003 |
0.214 |
-0.670 |
1.25 |
Phenol |
3.993 |
3.993 |
3.993 |
0.211 |
-0.677 |
1.32 |
Atrazine |
4.424 |
4.427 |
4.426 |
0.342 |
-0.466 |
1.81 |
Isoproturon |
4.777 |
4.778 |
4.778 |
0.448 |
-0.348 |
1.86 |
Triadimenol |
5.149 |
5.151 |
5.150 |
0.561 |
-0.251 |
2.40 |
Linuron |
5.933 |
5.937 |
5.935 |
0.799 |
-9.729 x 10-2 |
2.59 |
Naphthalene |
7.484 |
7.484 |
7.484 |
1.269 |
0.103 |
2.75 |
Endosulfan-diol |
5.824 |
5.823 |
5.824 |
0.765 |
-0.116 |
3.02 |
Fenthion |
9.646 |
9.646 |
9.646 |
1.924 |
0.284 |
3.31 |
Alpha-Endosulfan |
9.829 |
9.831 |
9.830 |
1.980 |
0.297 |
4.09 |
Phenanthrene |
12.924 |
12.923 |
12.924 |
2.918 |
0.465 |
4.09 |
Diclofop-methyl |
11.821 |
11.819 |
11.820 |
2.583 |
0.412 |
4.20 |
DDT |
27.412 |
27.428 |
27.420 |
7.313 |
0.864 |
5.63 |
Table 5.4.1/2: The retention times, capacity factor and log Koc values determined for the sample
Injection |
Retention time (mins) |
Capacity factor (k’) |
Log k’ |
Log Koc |
1 |
4.656 |
0.412 |
-0.386 |
1.906 |
2 |
4.656 |
0.412 |
-0.386 |
1.906 |
Description of key information
OECD Guideline 121, EU Method C.19, GLP, key study, validity 1:
Koc = 80.5; log Koc = 1.91
Highly mobile in soils (according to P.J. McCall et al., 1980).
Key value for chemical safety assessment
- Koc at 20 °C:
- 80.5
Additional information
One valid key study is available to assess the adsorption coefficient of the substance. This study was performed according to OECD Guideline 121 and EU Method C.19 with GLP statement. The test utilised a high performance liquid chromatograph (HPLC). A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
As the slope of the calibration curve for the reference standards showed good first order correlation and as the retention times between duplicate injections for the substance was similar, the HPLC method was considered valid for the determination of adsorption coefficient. All validity criteria were fulfilled.
The adsorption coefficient (Koc) of the substance has been determined to be 80.5 (log Koc = 1.91). The result indicates that the substance is highly mobile in soils (according to P.J. McCall et al., 19811).
1McCall P.J., Laskowski D.A., Swann R.L., and Dishburger H.J., (1981), “Measurement of sorption coefficients of organic chemicals and their use, in environmental fate analysis”, in Test Protocols for Environmental Fate and Movement of Toxicants. Proceedings of AOAC Symposium, AOAC,
Washington DC.
Mobility classification scheme:
Range of Koc |
Mobility class |
0 - 50 |
Very high |
50 - 150 |
High |
150 - 500 |
Medium |
500 - 2000 |
Low |
2000 - 5000 |
Slightly |
> 5000 |
Immobile |
[LogKoc: 1.91]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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