Registration Dossier
Registration Dossier
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EC number: 200-340-1 | CAS number: 57-57-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- grey literature
- Title:
- Development of standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories
- Author:
- Galloway et al.
- Year:
- 1 985
- Bibliographic source:
- Environ. Mutagen Vol. 7 (1985) 1-52
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.19 (Sister Chromatid Exchange Assay In Vitro)
- GLP compliance:
- not specified
- Type of assay:
- other: sister chromatid assay in mammalian cells
Test material
- Reference substance name:
- Propiolactone
- EC Number:
- 200-340-1
- EC Name:
- Propiolactone
- Cas Number:
- 57-57-8
- Molecular formula:
- C3H4O2
- IUPAC Name:
- oxetan-2-one
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- Chinese hamster Ovary (CHO)
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- not specified
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
