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Diss Factsheets
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EC number: 219-529-5 | CAS number: 2455-24-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- 1. SOFTWARE
---
2. MODEL (incl. version number)
screening model according to Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669.
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CC(=C)C(=O)OCC1CCCO1
molecular weight: 170.21 g/mol
log P: 1.35
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The physicochemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux has been calculated from modifications of the QSPeRs available for these compounds using the principles defined in the Potts and Guy prediction model.
The “Relative Dermal Absorption” potential assigned to the predicted skin flux for methacrylate data is an arbitrary estimation of skin penetration potential, and is not a regulatory or OECD approved classification. It is based on several hundred chemicals tested in the same human skin model at the Central Toxicology Laboratory and Dermal Technology Laboratory. This database includes a wide variety of pharmaceutical, agrochemical and industrial chemicals tested over a 20 year period. The dermal absorption potential of a particular chemical substance is placed into one of six categories based on its skin permeability coefficient or its predicted (or actual) absorption rate.
5. APPLICABILITY DOMAIN
The prediction model used in this investigation for a set of methacrylate chemicals is based on an established model (Potts and Guy, 1992), using data derived with human epidermal membranes.
6. ADEQUACY OF THE RESULT
If necessary, the prediction model and ranking of the methacrylate chemicals could be challenged using the INVEST (In Vitro Epidermal Screening Test), selecting a few at the high and low end of the ranking to determine the in vitro dermal penetration characteristics of specific chemicals in this series. This model is a rapid and costeffective screen using pig skin as a surrogate for human skin that has been used to rank examples from various chemical series. It is, of course, dependent on a suitable analytical method for the test chemical.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The physicochemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrahydrofurfuryl methacrylate
- EC Number:
- 219-529-5
- EC Name:
- Tetrahydrofurfuryl methacrylate
- Cas Number:
- 2455-24-5
- Molecular formula:
- C9H14O3
- IUPAC Name:
- (oxolan-2-yl)methyl 2-methylprop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): Tetrahydrofurfuryl methacrylate
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- not applicable; in silico modelling
Administration / exposure
- Type of coverage:
- other: not applicable; in silico modelling
- No. of animals per group:
- not applicable; in silico modelling
Results and discussion
- Absorption in different matrices:
- predicted flux: 28.461 µg/cm²/h; the relative dermal absorption is moderate
Any other information on results incl. tables
Based on a molecular weight of 170.21 g/mol and a log Kow of 1.35, the predicted flux of THFMA is 28.461 µg/cm²/h; the relative dermal absorption is moderate.
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of THFMA is predicted to be moderate; the predicted flux is 28.461 µg/cm²/h.
- Executive summary:
The dermal absorption (steady-state flux) of THFMA has been estimated by calculation using the principles defined in the Potts and Guy prediction model.
Based on a molecular weight of 170.21 g/mol and a log Kow of 1.35, the predicted flux of THFMA is 28.461 µg/cm²/h; the relative dermal absorption is moderate.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.