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EC number: 815-966-6 | CAS number: 915972-17-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From January 28, 2009 to October 5, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: JMAFF No 12 Nosan No 8147
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- [(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-(cyclopropanecarbonyloxy)-6,12-dihydroxy-4,6a,12btrimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-11H,12Hbenzo[f]pyrano[4,3-b]chromen-4-yl]methylcyclopropanecarboxylate
- EC Number:
- 815-966-6
- Cas Number:
- 915972-17-7
- Molecular formula:
- C33H39NO9
- IUPAC Name:
- [(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-(cyclopropanecarbonyloxy)-6,12-dihydroxy-4,6a,12btrimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-11H,12Hbenzo[f]pyrano[4,3-b]chromen-4-yl]methylcyclopropanecarboxylate
- Test material form:
- solid
- Details on test material:
- - Analytical purity: 96.1 %
- Appearance: Solid yellowish
- Batch: COD-001545
Constituent 1
- Specific details on test material used for the study:
- Lot number: 080722
Expiry: 29 July 2010
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fuji (Shizuoka, Japan).
- Females nulliparous and non-pregnant: Yes
- Age at study initiation: 9 weeks at dosing
- Weight at study initiation: 271- 283 g (male); 170-180 g (female)
- Fasting period before study: A fasting period was not reported
- Housing: Housed individually in metal cages (310 mm wide x 410 mm depth x 230 mm height)
- Diet: Scertified pellet diet MF (Lot No 081015, Oriental Yeast Co; Tokyo, Japan), ad libitum
- Water: Tap water, ad libitum
- Acclimation period: 9 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 2°C
- Humidity: 50 ± 20%
- Air changes: 10x or more per hour
- Photoperiod: 12 hours of artificial light (0700 – 1900 GMT) in each 24-hour period
IN-LIFE DATES: From Feb 19, 2009 to March 5, 2009
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorso-lumbar region; about 26hr prior to treatment, hair was removed with electric clippers, on the dorsal body surface area.
- Type of wrap: Surgical dressing pad moistened with 0.5 mL of distilled water, then applied to the 4 cm X 5 cm clipped skin area and occlusively held in place with surgical tape (Transpore TM).
REMOVAL OF TEST SUBSTANCE
- Washing: Residual test substance was washed off with warm water and neutral detergent
- Time after start of exposure: After 24 hours
TEST MATERIAL
- Concentration: 66.7% in 1% w/v aqueous methylcellulose
- Constant volume or concentration used: Yes
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were carefully observed for their mortalities, appearance, posture, behavior, respiration, consciousness, neurologic signs, body temperature, excretion, etc., at the time points of 1, 3 and 6 hours after administration and once daily thereafter until the termination of the observation period. Each animal was weighed on day of the administration shortly before dosing and on days 7 and 14 after administration.
- Necropsy of survivors performed: Yes
- Other examinations performed: Macroscopic examination consisted of opening the thoracic and abdominal cavities. The macroscopic appearance of all tissues including the dose sites was recorded. - Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed in this study.
- Clinical signs:
- other: No systemic clinical signs were observed during the study. There were no observed dermal responses.
- Gross pathology:
- Macroscopic examination revealed no abnormal findings in any of the animals at the termination of the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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