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Diss Factsheets
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EC number: 249-828-6 | CAS number: 29761-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Oral 90-d repeated dose toxicity study: LOAEL 10 mg/kg bw/day
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 10 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key study was a 90-day repeated dose toxicity oral feeding study, which was performed equivalent or similar to OECD408. Male and female rats were exposed to 0, 140, 1400, and 7000 ppm incorporated in the diet, resulting in doses of 0, 10, 100, and 500 mg/kg/bw/day. Rats were observed for mortality and clinical signs twice daily. Furthermore, body weight and food consumption was determined weekly. Haematology, clinical chemstry and urinalysis were measured at an interim measurement (6 -7 weeks) ant at termination (13 -24 weeks). Gross necropsy was performed animals from all doses, histopathology on animals from the control and high dose group.
Observed effects were reduced body weight gain, reduced food consumption, alterations in numbers of circulating red blood cells and red blood cell indices, decreased white blood cell values, decreased creatinine and serum glutamic oxaloacetic transaminae (SGOT), increased gamma glutamyl transpeptidase (gamma-GT), urobilinogen, urine bilirubin, cholesterol and phosphorus levels, as well as increased liver weights and hepatocellular hypertrophy/hyperplasia and hepatocellular brown pigment. As the effects on haematology parameters occurred at the lowest dose level, it was not possible to derive a NOAEL. The LOAEL was 140 ppm or 10 mg/kg bw/day.
A supporting 28 -day repeated dose toxicity oral feeding study was available in which Sprague-Dawley rats were exposed to IDDPP via the food. Tested dose levels were 0, 250, 500, 750, 1000, and 2000 mg/kg bw/day. Mortality, body weight, food consumption, and clinical signs were examined. After exposure, all animals were necropsied and gross pathology was performed.
Decrease in body weight gain in combination with decreased food consumption was observed in males in the three highest dose groups and in high dose females. No treatment-related deaths or clinical signs were observed. Hepatic enlargement and/or violet discoloration occurred in both males and females, but no statistics was performed to determine statistical significance.Therefore, no NOAEL could be established.
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: other
Justification for classification or non-classification
Based on the available information, no decision can be made concerning the classification of IDDPP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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