Registration Dossier
Registration Dossier
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EC number: 227-918-6 | CAS number: 6035-94-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authoritative Database.
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of C.I. Basic Red 9 in mouse
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of C.I. Basic Red 9 was performed in mouse.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- 4,4'-(4-iminocyclohexa-2,5-dienylidenemethylene)dianiline hydrochloride
- EC Number:
- 209-321-2
- EC Name:
- 4,4'-(4-iminocyclohexa-2,5-dienylidenemethylene)dianiline hydrochloride
- Cas Number:
- 569-61-9
- Molecular formula:
- C19H17N3.ClH
- IUPAC Name:
- 4,4'-(4-iminocyclohexa-2,5-dienylidenemethylene)dianiline hydrochloride
- Details on test material:
- - Name of test material (IUPAC name): 4,4'-(4-iminocyclohexa-2,5-dienylidenemethylene)dianiline hydrochloride
- Common name: C.I. Basic Red 9
- Molecular formula: C19H18ClN3
- Molecular weight: 323.825 g/mol
- Smiles notation: C(\c1ccc(N)cc1)(c1ccc(N)cc1)=C1/C=CC(=N)C=C1.Cl
- InChl: 1S/C19H17N3.ClH/c20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15;/h1-12,20H,21-22H2;1H
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):C.I. Basic Red 9
- Molecular formula:C19H18ClN3
- Molecular weight :323.825 g/mol
- Substance type:organic
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- 5000 mg/kg
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at dose level 5000 mg/kg bw
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 value was considered to be 5000 mg/kg,when mouse was treated with C.I. Basic Red 9 (569-61-9) orally.
- Executive summary:
Acute oral toxicity study was done in mouse using test material C.I. Basic Red 9 (569-61-9). 50% Mortality was observed at dose 5000 mg/kg bw.Hence,LD50 value was considered to be 5000mg/kg body weight when Mouse was treated with C.I. Basic Red 9 (569-61-9) orally.
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