Registration Dossier
Registration Dossier
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EC number: 219-440-1 | CAS number: 2437-25-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only 1-page summary was made available for this Guideline study performed under GLP.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Remarks:
- (Clariant information)
Test material
- Reference substance name:
- Dodecanenitrile
- EC Number:
- 219-440-1
- EC Name:
- Dodecanenitrile
- Cas Number:
- 2437-25-4
- Molecular formula:
- C12H23N
- IUPAC Name:
- dodecanenitrile
- Details on test material:
- Name: C12-Nitril
Synomyms: Laurylnitrile; Dodecanenitrile
CAS no.: 2437-25-4
Structural formula: C12 H23 N
Purity: > 99%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No information listed
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 24 hours, after which the eyes were flushed
- Observation period (in vivo):
- Not indicated
- Number of animals or in vitro replicates:
- Not indicated (Standard guidelines were followed: 3)
- Details on study design:
- No further information
Results and discussion
In vivo
- Irritant / corrosive response data:
- Not irritating
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not irrittating. No classification required.
- Executive summary:
Dodecanenitril was evaluated for eye irritation in New-Zealand rabbits according to OECD 405 and EU 84/449/EEC B.5 guidelines. 0.1 mL of undiluted test material was instilled in one eye of each animal. The eyes were flushed after 24 hours.
Results: No irritation was observed.
In conclusion: Dodecanenitrile is not irritating to the eyes.
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