Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 909-034-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1987-11-25 to 1987-12-04
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions: Incomplete documentation, TA 102 or E.coli WP2 were not tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- Method: other: Ames BN et al. (1975). Mutat. Res. 31, 347-364
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Cyclododecanol
- EC Number:
- 217-031-2
- EC Name:
- Cyclododecanol
- Cas Number:
- 1724-39-6
- Molecular formula:
- C12H24O
- IUPAC Name:
- cyclododecanol
- Details on test material:
- Cyclododecanol of Hüls AG, ID 423/870826, purity not reported
Constituent 1
Method
- Target gene:
- mutated gene loci responsible for histidine auxotrophy
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100
- Additional strain / cell type characteristics:
- other: histidine auxotroph
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor induced rat liver S9 mix, male Bor: W/SW (SPF/TNO) rats
- Test concentrations with justification for top dose:
- 10 to 5000 µg/plate
- Vehicle / solvent:
- acetone (CAS No. 67-64-1)
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- other: assumed to be performed but not reported
- True negative controls:
- no
- Positive controls:
- yes
- Remarks:
- details see below
- Positive control substance:
- other: without metabolic activation: Nitrofluorene (TA 98; TA 1538), Sodium azide (TA 100; TA 1535), Aminoacridine (TA 1537); with metabolic activation: Aminoanthracene (TA 100)
- Details on test system and experimental conditions:
- Ames test
SYSTEM OF TESTING
- Metabolic activation system: Aroclor induced rat liver S9 mix, male Bor: W/SW (SPF/TNO) rats, enzyme activity tested with aminoanthracene
ADMINISTRATION:
- Number of replicates: 2
- Application: solvent dimethyl sulfoxide (CAS No. 67-68-5)
- Positive and negative control groups and treatment:
2.5 µg nitrofluorene/plate: TA 98, TA 1538 (pos.)
2.5 µg sodium azide/plate: TA 100, TA 1535 (pos.)
50 µg aminoacridine/plate: TA 1537 (pos.)
negative: untreated plus solvent
- Pre-incubation: with and without - Evaluation criteria:
- CRITERIA FOR EVALUATING RESULTS: mutagenic effects (i.e ratio of revertant rates treated/control >= 2) at <= 5000 µg/plate with generally
positive dose-response relationship in any strain - Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: details: see "Test system"
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: at >= 250 or >= 500 µg/plate, respectively
- Vehicle controls validity:
- other: not reported but validity assumed
- Untreated negative controls validity:
- other: not reported but validity assumed
- Positive controls validity:
- other: not reportedabut validity assumed
- Additional information on results:
- no data
- Remarks on result:
- other: other: Salmonella typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
no other information
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The test substance cyclododecanol proved to be non-mutagenic under the conditions of this study, in absence and present of metabolic activation
system for all the test strains. - Executive summary:
The test substance cyclododecanol was tested in the Ames Salmonella/microsomes mutagenicity test for any mutagenic activity. The test organisms were five histidine-auxotrophic Salmonella typhimurium strains. The test substance concentrations were in the range between 10 and 5000 µg/plate. The test substance cyclododecane proved to be non-mutagenic under the conditions of this study, in absence and present of metabolic activation system for all the test strains.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.