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EC number: 619-290-0 | CAS number: 97780-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
- Deviations:
- yes
- Remarks:
- Verification of test conc., stability, and homogeneity in diluent not determined. Periodic analyses of water and feed for potential contaminants not performed according to GLP standards (done at certified laboratory and standard US EPA analytical methods)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.2100 (Avian Acute Oral Toxicity Test)
- Deviations:
- yes
- Remarks:
- Verification of test conc., stability, and homogeneity in diluent not determined. Periodic analyses of water and feed for potential contaminants not performed according to GLP standards (done at certified laboratory and standard US EPA analytical methods)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 002
- Cas Number:
- 97780-06-8
- Test material form:
- solid
- Details on test material:
- - Purity: 99.2%
Constituent 1
- Dose method:
- gavage
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- 1% CMC aqueous solution
Test organisms
- Test organisms (species):
- Colinus virginianus
Study design
- Post exposure observation period:
- 14 days
- No. of animals per sex per dose and/or stage:
- 5
- Control animals:
- yes, concurrent vehicle
- Nominal and measured doses / concentrations:
- Nominal: 0, 292, 486, 810, 1350, and 2250 mg a.s./kg bw
Examinations
- Reference substance (positive control):
- no
Results and discussion
Effect levelsopen allclose all
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 2 250 mg/kg bw
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: highest concentration tested
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 2 250 mg/kg bw
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- signs of toxicity
- Remarks on result:
- other: highest concentration tested
Applicant's summary and conclusion
- Conclusions:
- LD50 (Northern bobwhite): >2250 mg a.s./kg bw (highest concentration tested)
NOEL (Northern bobwhite): 2250 mg a.s./kg bw (highest concentration tested) - Executive summary:
The test substance was administered to fasted northern bobwhite quail (Colinus virginianus) in an acute oral toxicity study. The study was conducted according to EPA OPP 71-1 and EPA OPPTS 850.2100. Five male and five female bobwhites per dose received single oral nominal doses of 0, 292, 486, 810, 1350, and 2250 mg a.s./kg bw at a dose volume of 10 mL/kg bw in 1% CMC aqueous solution. Birds were observed for clinical signs of toxicity, body weight effects, and mortality for 14 days after dosing. Since there were no mortalities or signs of toxicity, no birds were examined for gross pathological changes. The acute oral LD50 value for northern bobwhite exposed to the test substance by single oral dose was >2250 a.s. /kg bw, the highest concentration tested. The no mortality and no-observed effect level was 2250 mg a.s./kg bw.
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