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Diss Factsheets
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EC number: 233-380-3 | CAS number: 10138-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- the number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 963
- Reference Type:
- secondary source
- Title:
- Toxicity
- Author:
- Haley T.J
- Year:
- 1 979
- Bibliographic source:
- Handbook on the Physics and Chemistry of Rare Earths, 553-585
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Europium trinitrate
- EC Number:
- 233-380-3
- EC Name:
- Europium trinitrate
- Cas Number:
- 10138-01-9
- Molecular formula:
- Eu.3HNO3
- IUPAC Name:
- europium trinitrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Europium nitrate
- Purity > 98%
- Other: Europium nitrate obtained from the Lindsay Chemical Company, West Chicago, Illinois, and the K and K Laboratories, Jamaica, New York. The six hydrate form was tested (6H2O).
No other information are available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: adult
- Weight at study initiation: 190 g to 250 g
- Fasting period before study: no data
- Housing: Animals were housed in air-conditioned quarters
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Aqueous solutions (pH 4.0 - 5.9) of the rare earth nitrates were prepared immediately before injection.
The solutions were given in single doses as 50% aqueous solutions. - Doses:
- Unknown
- No. of animals per sex per dose:
- 5 or 10 animals per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 30 days
- Statistics:
- On the basis of the mortality that occurred during the 30-day observation period, the LD50 values with 95% confidence limits were calculated by the method of Litchfield and Wilcoxon (1949).
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 704 mg/kg bw
- Based on:
- element
- Mortality:
- The animals were observed for 30 days although no deaths occurred later than 4 days after administration of the nitrate salts by the oral route.
- Clinical signs:
- other: Within 1 to 2 hours after oral administration of the rare earth nitrates, most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period.
- Gross pathology:
- Throughout the observation period no gross pathologic changes were noted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 of europium nitrate in female rats is higher than 5000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study (Bruce DW et al., 1963), female Sprague-Dawley rats were given a single doses of europium nitrate as 50% aqueous solution and then animals were observed for 30 days.
Within 1 to 2 hours after oral administration of the rare earth nitrates, most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period. The animals were observed for 30 days although no deaths occurred later than 4 days after administration of nitrate salts. Throughout the observation period no gross pathologic changes were noted.
The acute oral LD50 of europium nitrate in female rats was found to be higher than 5000 mg/kg bw.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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