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EC number: 281-013-0 | CAS number: 83833-37-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 = 4425 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 27, 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Tif: RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Females (if applicable) nulliparous and non-pregnant: [yes/no]
- Age at study initiation: 7 to 8 weeks old
- Fasting period before study: overnight before treatment
- Housing: animals were housed in groups of 5 in Macrolon cages (type 3), individually marked with picric acid.
- Diet: ad libitum rat food - NAFAG, Gossau SG
- Water: ad libitum
- Acclimation period: a minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2° C
- Humidity (%): 55 ± 10 %
- Photoperiod (hrs dark / hrs light): 10 hours light cycle day - Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- VEHICLE
- Lot/batch no. (if required): Fluka AG, Buchs SG, Art. 81170 - Doses:
- 10 and 20 ml/kg bw
- No. of animals per sex per dose:
- 5 per sex per dose
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals weight at day 1, 7 and 14
- Necropsy of survivors performed: yes. The surviving animals recovered within 8 days.
They were submitted to a necropsy whenever they died, survivors at the end of the observation period.
- Other examinations performed: clinical signs, body weight. - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 425 mg/kg bw
- Based on:
- test mat.
- Mortality:
- see table attached below
- Clinical signs:
- see table attached below
- Body weight:
- see table attached below
- Gross pathology:
- No substance related gross organ changes were seen.
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- LD50 = 4425 mg/kg bw
- Executive summary:
Method
The acute Oral Toxicity of the test substance has been investigated according to a procedure similar to the OECD guideline 401.
Results
LD50 = 4425 (3137-7295) mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 425 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Two studies have been reported that give information about Acute Oral Toxicity. In both studies the Acute Oral Toxicity of the test substance has been investigated according to a procedure similar to the OECD guideline 401.
In the key study the LD50 is 4425 (3137-7295) mg/kg bw while in the supporting study the LC50 value is 13120 in female rats and 16720 in male rats.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), substances can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to the numeric criteria. Acute toxicity values are expressed as (approximate) LD50 (oral, dermal) or LC50 (inhalation) values or as acute toxicity estimates (ATE).
In the case of oral exposure route, the acute toxicity hazard categories and acute toxicity estimates (ATE) defining the respective categories are:
- Category 1: ATE ≤ 5 mg/kg bw
- Category 2: 5 < ATE ≤ 50 mg/kg bw
- Category 3: 50 < ATE ≤ 300 mg/kg bw
- Category 4: 300 < ATE ≤ 2000 mg/kg bw
The LD50 in the key study is 4425 mg/kg bw. This value is over the limit of classification indicated in the CLP Regulation (EC 1272/2008), therefore the test substance is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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