Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 215-133-1 | CAS number: 1304-56-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Cutaneous Hypersensitivity to Beryllium
- Author:
- Curtis GH
- Year:
- 1 951
- Bibliographic source:
- A.M.A Archives of Dermatology and Syphilology
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A patch test was performed on 13 volunteers previously exposed to beryllium in the workplace and diagnosed with dermatitis.
- GLP compliance:
- no
- Type of study:
- patch test
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- BeF, ground beryllium metal, or undefined (water drippings from surface of overhead pipes coated with dust of various beryllium compounds
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- male
- Details on test animals and environmental conditions:
- A total of thirteen subjects diagnosed with dermatitis following occupational exposure to Be compounds: 10 subjects exposed to BeF, 2 subjects exposed to ground beryllium metal, and 1 subject exposed to undefined (water drippings from surface of overhead pipes coated with dust of various beryllium compounds.
The study also included a control group with 16 subjects who had never before been exposed to Be compounds.
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: dermal and inhalation
- Vehicle:
- other: moistened with water
Challenge
- Route:
- other: epicutaneous, cover not indicated
- Vehicle:
- other: moistened with water
- Details on study design:
- BeO was moistened and applied to the skin for 48 hours. The results were read after 48 or 72 hours.
Results and discussion
Any other information on results incl. tables
None of the subjects tested positive for BeO sensitivity in a patch test. There was also no reaction in 16 volunteers not previously exposed to Be compounds.
Other compounds tested included BeFl2, BeSO4, BeCl2, Be(NO3)2 in addition to Be metal. These compounds tested positive to various degrees. Some of these compounds also caused "spontaenous flare-ups" in the control cohort with no prior exposure to beryllium compounds. This was not observed with BeO.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- BeO did not cause a skin reaction in a patch test performed on human subjects previously exposed to various Be compounds and diagnosed with dermatitis.
- Executive summary:
A patch test was performed on human subjects diagnosed with dermatitis following work exposure to Be compounds (BeFl2, Be metal or various Be dust in water drippings). BeO was moistened and applied to the skin for 48 hours. The reaction was interpreted after 48 or 72 hours.
No reaction was seen in the subjects exposed to BeO. Subjects exposed to BeFl2, BeSO4, BeCl2, Be(NO3)2 tested positive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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