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EC number: 805-172-8 | CAS number: 65646-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 April 2016 - 05 July 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- gas chromatography (GC)
- Details on sampling:
- The test samples were thawed with the aid of sonication. The test samples (100 mL) plus 30 g of sodium chloride were extracted with 100 mL of hexane . An aliquot of the hexane layer was taken for analysis.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna is a freshwater invertebrate representative of a wide variety of natural habitats, and can therefore be considered as an important non-target organism in freshwater ecosystems.
- Test type:
- static
- Water media type:
- other:
- Remarks:
- Reconstituted water (ISO medium) used for both the range-finding and definitive tests
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- approximate theoretical total hardness of 250 mg/L
- Test temperature:
- maintained at 21 °C to 22 °C
- pH:
- 0 hours: 7.6; 48 hours: 7.9-8.0
- Dissolved oxygen:
- 0 hours (mg O2/L): Control:7.9 ; 10%v/v: 7.3; 18%v/v: 7.3; 32%v/v: 7.4; 56%v/v: 7.8; 100%v/v: 8.6
48 hours (mg O2/L): Control:8.9 ; 10%v/v: 8.6; 18%v/v: 8.6; 32%v/v: 8.6; 56%v/v: 8.6; 100%v/v: 8.6 - Nominal and measured concentrations:
- 10, 18, 32, 56 and 100% v/v saturated solution for 48 hours
After 24 hours: 10, 1.0 and 0.10% v/v saturated solution - Details on test conditions:
- photoperiod of 16 hours light (between 200 and 1200 Lux) and 8 hours darkness with 20 minute dawn and dusk transition periods.
- Reference substance (positive control):
- yes
- Remarks:
- The results from the positive control with potassium dichromate were within the normal range for this reference item.
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 19 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- 95% Confidence limits (mg/L):17-21
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 26 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Sub-lethal effects of exposure were observed in the 14 mg/L test concentration. This response was reduced mobility at both 24 and 48 hours.
- Results with reference substance (positive control):
- The results from the positive control with potassium dichromate were within the normal range for this reference item.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Exposure of Daphnia magna to the test item has been investigated and gave the following results based on the geometric mean measured test concentrations:
Time Point (Hours)- 48
EC50 (mg/L)- 13
95% Confidence Limits (mg/L)- Not determined
No Observed Effect Concentration (NOEC) (mg/L)-6.8
Lowest Observed Effect Concentration (LOEC) (mg/L)-14
Reference
Description of key information
Exposure of Daphnia magna to the test item has been investigated and gave the following results based on the geometric mean measured test concentrations:
Time Point (Hours)- 48
EC50 (mg/L)- 13
95% Confidence Limits (mg/L)- Not determined
No Observed Effect Concentration (NOEC) (mg/L)-6.8
Lowest Observed Effect Concentration (LOEC) (mg/L)-14
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 13 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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