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EC number: 435-580-8 | CAS number: 56553-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin: not irritating (OECD 404)
Eye: irreversibkle effects (OECD 405)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-07-27 - 2004-09-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study according GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health, 2003
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Scientifique des Dombes, F-01400 Chatillon sur Chalaronne, France
- Age at study initiation: 13 weeks (males), 11 weeks (females)
- Weight at study initiation: 2306 g (male), 2398 g and 2335 g (females)
- Housing: Individually in stainless steel cages equipped with feed hoppers and drinking water bottles. Wood blocks (RCC Ltd., Füllinsdorf) and haysticks 4642 (batch no. 15/04, Provimi Kliba AG) were provided for gnawing
- Diet (e.g. ad libitum): Pelleted standard Provimi Kliba 3418 rabbit maintenance diet batch no. 33/04 (Provimi Kliba AG, CH-4303 Kaiseraugst, Switzerland); ad libitum
- Water (e.g. ad libitum): Community tap water from Füllinsdorf; ad libitum
- Acclimation period: Under laboratory conditions after health examination
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 23
- Humidity (%): 30 - 70
- Air changes (per hr): 10 - 15
- Photoperiod (hrs dark / hrs light): 12 /12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4
- Observation period:
- 14 days
Reading time points: 1, 24, 48 and 72 h and 7, 10 and 14 days - Number of animals:
- 1 male, 2 females
- Details on study design:
- TEST SITE
- Area of exposure: 10x10 cm of left flank
- Type of wrap if used: Surgical gauze patch (4x4 cm) covered with semi-occlusive dressing warpped around the abdomen
REMOVAL OF TEST SUBSTANCE
- Washing (if done): lukewarm tap water
- Time after start of exposure: 4 h
SCORING SYSTEM:
According to EEC Commision Directive 2004/73/EC, April 29, 2004 - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 1.67
- Max. score:
- 2
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- The animal with moistened skin prior to application showed very slight to well-defined erythema from 24h to day 7. Scaling was obserevd in this animal up to day 10. The other animals showed only very slight effcets 1 hour after application, which were completely reversibkle within 24 h.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Sodium triacetoxyborohydride was found to be not irritating to skin based on the mean erythema scores of 0, 1.67 and 0, and the edema scores of 0 after 24,48 and 72 h in the three treated rabbits, respectively.
- Executive summary:
Sodium triacetoxyborohydride was tested for irritating properties in a GLP study performed according to OECD 404. 0.5 grams of Sodium triacetoxyborohydride was applied to the skin of three New Zealand White rabbits for 4 h under semi-occlusive conditions and the sites were evaluated for effects for 14 day. The mean erythema and edema scores after 24,48 and 72 h in the three rabbits were 0, 1.67, 0 (erythema) and 0 (edema), respectively. Thus, Sodium triacetoxyborohydride was found to be not irritating to skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-08-24 - 2004-10-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study according GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only 1 animal was treated, remaining two animals were not treated due to severe effects
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only 1 animal was treated, remaining two animals were not treated due to severe effects
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health, 2003
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Elevage Scientifique des Dombes, F-01400 Chatillon sur Chalaronne, France
- Age at study initiation: 11 weeks (female)
- Weight at study initiation: 2263 g
- Housing: Individually in stainless steel cages equipped with feed hoppers and drinking water bottles. Wood blocks (RCC Ltd., Füllinsdorf) and haysticks 4642 (batch no. 15/04, Provimi Kliba AG) were provided for gnawing
- Diet (e.g. ad libitum): Pelleted standard Provimi Kliba 3418 rabbit maintenance diet batch no. 33/04 (Provimi Kliba AG, CH-4303 Kaiseraugst, Switzerland); ad libitum
- Water (e.g. ad libitum): Community tap water from Füllinsdorf; ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 23
- Humidity (%): 30 - 70
- Air changes (per hr): 10 - 15
- Photoperiod (hrs dark / hrs light): 12 /12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Duration of treatment / exposure:
- Single application without washing
- Observation period (in vivo):
- 21 days
Reading time points: 1, 24, 48 and 72 h and 7, 10, 14, 17 and 21 days - Number of animals or in vitro replicates:
- 1 female
- Details on study design:
- SCORING SYSTEM:
According to EEC Commision Directive 2004/73/EC, April 29, 2004
TOOL USED TO ASSESS SCORE: hand-slit lamp (Varta Cliptrix diagnostic lamp (Roth AG, CH-4135 Reinach, Switzerland) - Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: Mean 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 21 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: Mean 24, 48 and 72 h
- Score:
- 0.67
- Max. score:
- 2
- Reversibility:
- fully reversible within: 17 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: Mean 24, 48 and 72 h
- Score:
- 1.67
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: Mean 24, 48 and 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritant / corrosive response data:
- Corneal opacity: very sligh to moderate from 1h to day 21
Iris: reduced light effect from 48 h to day 7 and on day 14. Absence of light reflex on day 10
Conjunctivy: sligh to moderate from 1h to day 21
Chemosis: marked swelling with half-closed lid or closed lid from1 to 72 h. Obvious swelling with partial eversion of lid up to day 21
Sclera: redding from 1 to 72 h, marked to slight redding from day 7 to 21
Discharge: marked from 48 to day 7 - Other effects:
- No cinical sings of systemic roxicity was observed and no mortality occured.
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the effect on cornea and conjunctivae still persistent on day 21 at the end of observation period, Sodium triacetoxyborohydride was found to have irreversible effects on the eye.
- Executive summary:
Sodium triacetoxyborohydride was tested for irritating properties in a GLP study performed according to OECD 405. Since irritating effects were expected, 0.1 g of Sodium triacetoxyborohydride was instilled in the eye of only one New Zealand White rabbit. The mean scores for corneal opacity, iris, conjunctival erythema and chemosis were 2, 0.67, 1.67 and 4.0, respectively. In addition, the strong effects on cornea and conjunctivae still persistent on day 21 at the end of observation period, so that Sodium triacetoxyborohydride was found to have irreversible effects on the eye.
Reference
BAsed on the sever effects in the treated animl, no further animals were treated.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Sodium triacetoxyborohydride was tested for irritating properties in a GLP study performed according to OECD 404. 0.5 grams of Sodium triacetoxyborohydride was applied to the skin of three New Zealand White rabbits for 4 h under semi-occlusive conditions and the sites were evaluated for effects for 14 day. The mean erythema and edema scores after 24,48 and 72 h in the three rabbits were 0, 1.67, 0 (erythema) and 0 (edema), respectively. Thus, Sodium triacetoxyborohydride was found to be not irritating to skin.
Sodium triacetoxyborohydride was tested for irritating properties in a GLP study performed according to OECD 405. Since irritating effects were expected, 0.1 g of Sodium triacetoxyborohydride was instilled in the eye of only one New Zealand White rabbit. The mean scores for corneal opacity, iris, conjunctival erythema and chemosis were 2, 0.67, 1.67 and 4.0, respectively. In addition, the strong effects on cornea and conjunctivae still persistent on day 21 at the end of observation period, so that Sodium triacetoxyborohydride was found to have irreversible effects on the eye.
Justification for selection of skin irritation / corrosion endpoint:
Reliable OECD guideline study according to GLP
Effects on eye irritation: corrosive
Justification for classification or non-classification
The available data on irritation/corrosion of the test substance meet the criteria for classification as Eye Damage 1 (H318: Causes serious eye damage) according to Regulation (EC) 1272/2008.
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