Registration Dossier
Registration Dossier
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EC number: 207-872-3 | CAS number: 498-94-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: AFNOR T03-021
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-piperidinecarboxylic acid
- EC Number:
- 207-872-3
- EC Name:
- 4-piperidinecarboxylic acid
- Cas Number:
- 498-94-2
- Molecular formula:
- C6H11NO2
- IUPAC Name:
- piperidine-4-carboxylic acid
- Test material form:
- solid
- Details on test material:
- lot n°003
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA CREDO
- Weight at study initiation: around 125g
- Housing: dust free sterilised sawdust
- Diet (e.g. ad libitum): sterilised
- Water (e.g. ad libitum): pH 3.5 ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/-1°C
- Humidity (%): 60 +/-10%
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10 ml/kg
MAXIMUM DOSE VOLUME APPLIED: 5 g/kg
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 10 males + 10 females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: observation after 15 minutes, 1 hour, 2 hours, 6 hours and then each day ; weighing on days 0, 5, 10 and 15.
- Necropsy of survivors performed: yes on all animals
Results and discussion
- Preliminary study:
- done with 4 males per dose at 0.25 g/kg, 0.5 g/kg, 1 g/kg, 2 g/kg and 5 g/kg
No mortality observed
Effect levels
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- no mortality
- Clinical signs:
- other: no clinical signs
- Gross pathology:
- no pathology observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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