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EC number: 305-224-5 | CAS number: 94350-05-7 Substance obtained by acidic, alkaline, or enzymatic hydrolysis of rice bran composed primarily of amino acids, peptides, and proteins. It may contain impurities consisting chiefly of carbohydrates and lipids along with smaller quantities of miscellaneous organic substances of biological origin.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March - April 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Protein hydrolyzates, rice bran
- EC Number:
- 305-224-5
- EC Name:
- Protein hydrolyzates, rice bran
- Cas Number:
- 94350-05-7
- IUPAC Name:
- Protein hydrolyzates of Oryza Sativa
- Test material form:
- liquid
- Details on test material:
- yellow liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New-Zealand
- Details on test animals or test system and environmental conditions:
- - Source: ESD 01400 ROMANS
- Weight at study initiation: about 2 to 2.5 kg at the time of trial
- Housing: Animals were kept in individual metal cages of standardized dimensions with perforated floor.
These cages are placed in a temperature controlled animal shelter where the temperature is between 18°C and 22°C and the relative humidity is maintained at between 30% and 80%. The air is filtered.
- Diet (e.g. ad libitum): ref 112; UAR - 91360 EPINAY SUR ORGE
- Water (e.g. ad libitum): Tap filtered water provided ad libitum with automatic pipettes.
- Acclimation period: 5 days at least
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 ml of product
- Duration of treatment / exposure:
- the dressing is removed after 4 hours.
- Observation period:
- The irritation is measured 1 hour after removing the dressing, then the rating is repeated at hour 24 hours, 48 hours, 72 hours until day 7 if necessary.
If the irritation persists after day 7, the observations are extended until reversibility without exceeding a 14 day period. - Number of animals:
- 3 rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- other: the 3 rabbits
- Time point:
- other: 1h, 24h, 48h, 72h
- Score:
- ca. 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item has a very slight irritant power according to the protocol defined in the Official EEC Gazette of September 19, 1984.
In these conditions, the product does not provoke any specific irritant skin lesions. - Executive summary:
The test item was administered pure to 3 New Zealand rabbits at the dose of 0.5 ml. The experimental protocol was established according to the official in the Official EEC Gazette of September 19, 1984 and OECD guideline 404.
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