Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-603-0 | CAS number: 993-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No irritation data are available for the registered substance. Data are available for the structural analogue, triethylsilane (CAS 617-86-7), from skin and eye irritation studies conducted in accordance with OECD 404 and 405 respectively and in compliance with GLP. Triethylsilane was not irritant in rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are no data available to assess the skin and eye irritation potential of trimethylsilane, and testing is not technically feasible because the substance is a gas. Therefore data for the structural analogue substance triethylsilane (CAS 617-86-7) have been used to assess its skin and eye irritation potential. Triethylsilane was found to be not irritating to rabbit skin and eyes.
Information on triethylsilane is included for completeness only.
Read-across justification
To reduce animal testing REACH recommends to make use of a read-across approach where appropriate based on the high accordance in properties relevant for the specific endpoint. In the case of irritation the relevant properties are structural similarity as well as physical-chemical properties in the same range. In the following paragraphs the proposed read-across from triethylsilane to trimethylsilane is discussed. A report considering read across for all endpoints is attached in Section 13.
Read-across hypothesis
The hypothesis is that source and target substances have similar toxicological properties because they are structurally similar and have similar physicochemical properties. Trimethylsilane has a half-life in water of days and triethylsilane is hydrolytically stable, so reaction products do not need to be considered for the human health hazard assessment of these substances.
Read-across justification
(a) Structural similarity
The registration and read-across substances are structurally similar and are members of an analogue group of alkylsilanes. The substances contain a silicon atom to which is attached three alkyl (methyl/ethyl) groups. For the registered substance the alkyl groups are methyl, for the read-across substance they are ethyl. It is not considered likely that decreasing the carbon chain length by one carbon would be likely to confer additional irritation properties on the registration substance; however, this cannot be demonstrated experimentally due to the physical state of trimethylsilane at ambient temperature and pressure.
(b) Similar physicochemical characteristics
The key physicochemical parameters are summarised below.
Table: Key physicochemical parameters
CAS number |
000993-07-7 |
000617-86-7 |
EC number |
213-603-0 |
210-535-3 |
Chemical Name |
Trimethylsilane |
Triethylsilane |
Molecular weight (gmol-1) |
74.20 |
116.28 |
log Kow (parent) |
2.2 |
3.6 |
Water solubility (parent) |
1400 mg/l (QSAR), limited by condensation reactions following abiotic reaction to silanol |
6 mg/l |
Vapour pressure (parent) |
not applicable (substance is a gas) |
2700 Pa |
Justification for classification or non-classification
Based on available information for the read-across substance triethylsilane, the registered substance, trimethylsilane, does not require classification for skin and eye irritation according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.