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EC number: 216-938-0 | CAS number: 1703-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from NTP and NTRL report.
- Justification for type of information:
- Data is from NTP and NTRL report.
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative database.
- Title:
- Study of Inhalation Toxicity in rats.
- Author:
- Arthur D. Little, Inc.
- Year:
- 1 991
- Bibliographic source:
- NATIONAL TOXICOLOGY PROGRAM, EXECUTIVE SUMMARY OF SAFETY AND TOXICITY INFORMATION, 4 October 1991
- Reference Type:
- secondary source
- Title:
- Inhalation Toxicity in rats.
- Author:
- Mallinckrodt INC
- Year:
- 1 980
- Bibliographic source:
- NTIS Report, OTS02800059
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To access the effect of Butane-1,2,3,4-tetracarboxylic acid in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Butane-1,2,3,4-tetracarboxylic acid
- EC Number:
- 216-938-0
- EC Name:
- Butane-1,2,3,4-tetracarboxylic acid
- Cas Number:
- 1703-58-8
- Molecular formula:
- C8H10O8
- IUPAC Name:
- butane-1,2,3,4-tetracarboxylic acid
- Test material form:
- solid
- Details on test material:
- - Name of the test chemical: Butane-1,2,3,4-tetracarboxylic acid- IUPAC name: Butane-1,2,3,4-tetracarboxylic acid - Molecular Formula: C8H10O8- Molecular Weight: 234.159 g/mol- Smile Notation: OC(=O)C[C@H]([C@H](CC(=O)O)C(=O)O)C(=O)O- InChI : 1S/C8H10O8/c9-5(10)1-3(7(13)14)4(8(15)16)2-6(11)12/h3-4H,1-2H2,(H,9,10)(H,11,12)(H,13,14)(H,15,16)/t3-,4+- Substance type: organic
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: Butane-1,2,3,4-tetracarboxylic acidMolecular Formula: C8H10O8Molecular Weight: 234.159 g/molSmile Notation: OC(=O)C[C@H]([C@H](CC(=O)O)C(=O)O)C(=O)OInChI : 1S/C8H10O8/c9-5(10)1-3(7(13)14)4(8(15)16)2-6(11)12/h3-4H,1-2H2,(H,9,10)(H,11,12)(H,13,14)(H,15,16)/t3-,4+Substance type: organic Physical state: Solid
Test animals
- Species:
- rat
- Strain:
- other: COX-SD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: No dataAge at study initiation: No dataWeight at study initiation:198-293gmFasting period before study: yes, overnight fasting Housing: Metal wire bottomed cagesDiet (e.g. ad libitum): Purina Rodent Laboratory Chow, ad libitiumWater (e.g. ad libitum):Tap water, ad libitium Acclimation period: No data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: dust
- Details on inhalation exposure:
- - Weight at study initiation:Animal NoSexInitial weight(g)1M2562M2563M2464M2575M2726F2427F2418F2519F23010F251- Fasting period before study: No- Housing: Metal Wire Bottomed cages- Diet (e.g. ad libitum): Purina Rodent Laboratory Chow(pellitized),ad libitium- Water (e.g. ad libitum):tap water, ad libitum- Acclimation period: Not dataENVIRONMENTAL CONDITIONS- Temperature (°C): Not data- Humidity (%): Not data- Air changes (per hr):Not data- Photoperiod (hrs dark / hrs light): Not data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Remarks on duration:
- 60 minutes (plus a 23 minute equilibration period).
- Concentrations:
- 1.7 grams of the substance
- No. of animals per sex per dose:
- 5 animals per sex
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?): 14 day observation period- Frequency of observations and weighing: 1 day, 7 day and 14 day- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: body weight and lung observations
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 8.19 other: mg
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: LC 0 value was observed
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No data available
- Body weight:
- Body weight showed weight gain within the expected limits.
- Gross pathology:
- moderate congestion of the lungs in three of the ten animals were observed. It is not possible to assign acause effect relation to the lung congestion, but this type of congestion is often observed as a sacrifice artifact in rats.
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Conclusions:
- At a flow concentration of approximately 8.19 mg per liter of air and flow rate of 2.5 liters per minute for a period of 60 minutes plus 23 minutes equilibration time, all of the test animals survived. The LD50 for butane tetracarboxylic acid >8.19 mg/lt of air.
- Executive summary:
Ten albino rats (five male and five female, COX-SD strain), weighing 230 to 272 grams, were exposed by the route of inhalation to undiluted butane tetracarboxylic acid in the powder form at a delivery flow concentration of approximately 8.19 mg per liter of air at a flow rate of 2.5 liters per minute for a period of 60 minutes plus 23 minutes for equilibration. All of the animals survived the 60 minute exposure and the 14 day observation period which followed. Body weight gain was observed.No sign of gross toxicity was observed in any animal after post exposure observation period. 3 of the 10 animals shows lung congestion and other animals were not remarkable.
On the basis of observation,the LD 50 value for butane tetracarboxylic acid was considered to be >8.19 mg/l of air concentations.
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