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EC number: 214-463-3 | CAS number: 1131-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial Risk-Based Prioritization of High Production Volume (HPV) Chemicals, CAS no: 102-06-7 1, 3-Diphenylguanidine
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 009
- Bibliographic source:
- U.S. Environmental Protection Agency Risk-Based Prioritization Document, April 2009
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Skin sensitization study of 1, 3-Diphenylguanidine was performed in guinea pig by Guinea pig maximization test
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Not specified.
Test material
- Reference substance name:
- 1, 3-Diphenylguanidine
- Cas Number:
- 102-06-7
- Molecular formula:
- C13H13N3
- IUPAC Name:
- 1, 3-Diphenylguanidine
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): 1, 3-Diphenylguanidine
- Molecular formula: C13H13N3
- Molecular weight:211.267 g/mole
- Substance type: organic
- Physical state: solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1, 3-Diphenylguanidine
- Molecular formula: C13H13N3
- Molecular weight:211.267 g/mole
- Substance type: organic
- Physical state: solid
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: intradermal and epicutaneous, occlusive
- Vehicle:
- paraffin oil
- Concentration / amount:
- Intradermal injection :0.1ml of 1.0%w/w
Topical application :0.5ml of 25%w/w - Day(s)/duration:
- 48hr
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- paraffin oil
- Concentration / amount:
- 0.5ml of 25%w/w
- Day(s)/duration:
- 24hr
- No. of animals per dose:
- Total :15
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures:2
- Exposure period:48hr
- Test groups:15
- Control group: No data available
- Site: No data available
- Frequency of applications: on day 1 intradermal injection
On day 8 cutaneous application
- Duration:48hr
- Concentrations: Intradermal injection :0.1ml of 1.0%w/w
Topical application :0.5ml of 25%w/w
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: 12 days
- Exposure period: 24hr
- Test groups: 15
- Control group: No data available
- Site: No data available
- Concentrations: 0.5ml of 25%w/w
- Evaluation (hr after challenge): 24hr and 48hr
OTHER: Freund’s complete adjuvant was given during intradermal induction - Challenge controls:
- No data available
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.5 mL of 25% (w/w)
- No. with + reactions:
- 0
- Total no. in group:
- 15
- Clinical observations:
- No sensitization reaction was observed
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- Test material was not skin sensitizing in guinea pig
In vivo (LLNA)
- Cellular proliferation data / Observations:
- CLINICAL OBSERVATIONS: No skin sensitization reaction was observed.
Any other information on results incl. tables
No skin sensitization reaction was observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The skin sensitization study of 1, 3-Diphenylguanidine (102-06-7) was performed in guinea pig . The test result was determined to be not sensitizing.
- Executive summary:
The skin sensitization study of 1, 3-Diphenylguanidine (102 -06 -7) was performed in 15 guinea pigs by using Guinea pig maximization test.In induction phase, on 1stday intradermal injection of 0.1ml of 1.0%w/w1, 3-Diphenylguanidine in paraffin oil in presence ofFreund’s complete adjuvant was given .on day 8, occlusive dressing of0.5 ml of 25%w/w1, 3-Diphenylguanidine in paraffin oil was applied for 48hr.In challenge phase, after 12 days 0.5 ml of 25%w/w1, 3-Diphenylguanidine in paraffin oil was applied for 24hr, as occlusive patch. The evolution done 24hr and 48hr after removal of challenge application.No sensitization reaction was observed at application site .Hence it is considered that 1, 3-Diphenylguanidine(102 -06 -7) was not skin sensitizing in guinea pig.
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