3-phenylpropionic acid

Density

Link to relevant study record(s)

Reference

Endpoint:

density

Remarks:

density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-03-01 – 2017-03-01

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental result performed using standard methods of analysis

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density is calculated from the difference in weight between the full and empty pycnometer and its volume

GLP compliance:

no

Type of method:

other: Pour and tapped density

Specific details on test material used for the study:

- Name of test material (as cited in study report): 3-phenylpropanoic acid
- Molecular formula :C9H10O2
- Molecular weight : 150.176 g/mol
Substance type:Organic
- Physical state:Solid

Key result

Type:

pour density

Density:

0.607 g/cm³

Temp.:

26.4 °C

Key result

Type:

tap density

Density:

0.743 g/cm³

Temp.:

26.4 °C

Method Details		Observations
Guideline	OECD 109	1^stReading	2^ndReading
Method	Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014
Principle of method	Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density: It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.
Test temperature (°C)		26.6 °C	26.3 °C
Atmospheric pressure (in hPa)		978.7	978.5
Weight of test item(m)		20.021	20.020
Volume of measuring cylinder; readability in g		50ml ; 1 ml	50 ml; 1ml
Volume of test item without tapping (V)		34	32
Volume of test item after tapping ( V1)	After 10 tapping	30	28
	After 50 tapping	28	26
	After 100 tapping	28	26
	After 250 tapping	-	-
	After 500 tapping	-	-
	After 750 tapping	-	-

 

CALCULATIONS:

By Pour Density and Tapped Density Method:

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	m/v	0.5888	0.6256	0.6072
Tap density of test Item (g/cm³)	m/v	0.7150	0.7700	0.7425

Conclusions:

The density of test item 3-phenylpropionic acid (CAS No. 501-52-0)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.6072 g/cm³ and 0.7425 g/cm³at 26.4°C and 978.6 hPa.

Executive summary:

The density of test item 3-phenylpropionic acid (CAS No. 501-52-0)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.6072 g/cm³ and 0.7425 g/cm³at 26.4°C and 978.6 hPa.

Description of key information

The density of test item 3-phenylpropionic acid (CAS No. 501-52-0)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.6072 g/cm³ and 0.7425 g/cm³at 26.4°C and 978.6 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.607

Additional information

The density of test item 3-phenylpropionic acid (CAS No. 501-52-0)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.6072 g/cm³ and 0.7425 g/cm³at 26.4°C and 978.6 hPa.

Other supporting studies from various from reliable sources such  as authoritative database and handbooks,the density of chemical 3-phenylpropanoic acid was determined to be 1.0715g/cm3 at 48.7 degree C.

As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of density as 0.6072 g/cm3 (pour density) and 0.7425 g/cm3(tapped density) thus considered as key study for the chemical safety assessment