Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-623-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study initiation date: September 28, 1995 to Study completion date: October 10, 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- yes
- Remarks:
- Preparation of the inoculum : higher sludge weight after the washing procedure (Sludge concentrations in the test according to the guidelines). - 4 instead of 5 test concentrations
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Code number: FAT 92504/A
Batch-Nr.: 1/95
Purity: 46 %
Appearance: solid
Solubility: <0.1 g/l [in water]
Storage: room temperature
Expiration date: 04/99 - Analytical monitoring:
- yes
- Vehicle:
- not specified
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- Organism: Activated sludge of a communal sewage treatment plant (ARA-Pro Rheno Basel), collected on October 3, 1995.
Sludge pretreatment: 3 times washing with tap water and addition of synthetic sewage feed (a day before the main test). - Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20 ± 2 °C
- pH:
- 7.8 before the test beginning
- Nominal and measured concentrations:
- Test concentrations : 320, 100, 32 and 10 mg/l of the test substance.
32, 10 and 3.2 mg/l of the reference substance. - Details on test conditions:
- Experimental conditions
Temperature: 20 ± 2 °C
Sludge dry weight: 1.44 g/l
Test volume: 100 ml
Test duration: 3 h
Aeration: 0.1 - 0.2 l/min by Pasteur-pipette
pH of sludge: 7.8 before the test beginning
Estimation technic: O2 - consumption, measured with an oxygen sensitive electrode system: OXI DIGI 530 (SAV : 00 109) - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol for synthesis (Merck 821768)
- Key result
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- The % inhibition observed was 0, 2.5, 0 and 0 % at 10, 32, 100 and 320 mg/L, respectively.
- Results with reference substance (positive control):
- The IC50 (3 h) of the reference substance 3,5-Dichlorophenol: 14 mg/l
- Validity criteria fulfilled:
- yes
- Conclusions:
- IC50 (3 h) of the test substance FAT 92504/A was determined to be >320 mg/l.
- Executive summary:
The toxicity of FAT 92504/A to activated sludge was determined in a 3-hours respiration inhibition test according to the EEC Directive 87/302, L 133/118 -122 and to the OECD Guideline No. 209. The test substance concentrations tested were 320, 100, 32 and 10 mg/l. The reference substance, 3,5-Dichlorophenol was tested in concentrations of 32, 10 and 3.2 mg/l. The % inhibition observed was 0, 2.5, 0 and 0 % at 10, 32, 100 and 320 mg/L, respectively. Based on the findings of the study, IC50 (3 h) of the test substance FAT 92504/A was determined to be >320 mg/l, while the IC50 (3 h) of the reference substance 3,5-Dichlorophenol was 14 mg/l.
Reference
Description of key information
The toxicity of FAT 92504/A to activated sludge was determined in a 3-hours respiration inhibition test according to the EEC Directive 87/302, L 133/118 -122 and to the OECD Guideline No. 209. The test substance concentrations tested were 320, 100, 32 and 10 mg/L. The % inhibition observed was 0, 2.5, 0 and 0 % at 10, 32, 100 and 320 mg/L, respectively. Based on the findings of the study, IC50 (3 h) of the test substance FAT 92504/A was determined to be >320 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 320 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.