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EC number: 213-773-6 | CAS number: 1009-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988-08-11 to 1989-02-22
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The restrictions were that the test concentration was not the maximum concentration for vapours and no analythical verification of the test concentration was performed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- The study does not meet current guideline requirements.
- GLP compliance:
- yes
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2,4,4,6,6-hexamethylcyclotrisilazane
- EC Number:
- 213-773-6
- EC Name:
- 2,2,4,4,6,6-hexamethylcyclotrisilazane
- Cas Number:
- 1009-93-4
- Molecular formula:
- C6H21N3Si3
- IUPAC Name:
- 2,2,4,4,6,6-hexamethyl-1,3,5,2,4,6-triazatrisilinane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Basic Material Business, BB058016
FORM AS APPLIED IN THE TEST (if different from that of starting material): vapour
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, USA
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: no data
- Weight at study initiation: 175 - 200 g
- Fasting period before study: no data
- Housing: In stainless steel, wire mesh bottomed cages of convensional design
- Diet: ad libitum except during the exposure period
- Water: ad libitum except during the exposure period
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C
- Humidity (%): 30 - 50 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remark on MMAD/GSD:
- No data
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Stainless steel and glass chamber
- Exposure chamber volume: 450-liter
- Method of holding animals in test chamber: no data
- Source and rate of air: Air passed through a J-tube and rate of the airflow was monitored by Magnehelic gauges. A glass J-tube with a low flow FMI Lab pump was used to introduce test material into the chamber. Filtered laboratory air passed through the J-tube. The air/ vapour mixture entered the top of the chamber where it was diluted with room air. Heating tape was used to heat the air which passed through the J-tube, and glass beads were used to help vaporise the test material.
- Method of conditioning air: Matheson 462 cartridge filter
- Treatment of exhaust air: the exhaust air was filtered (hepa and carbon), cleaned with a water cyclone, then exhausted from the roof of the building.
- Temperature, humidity, pressure in air chamber: Chamber temperature and relative humidity were monitored with Cole-Primer Model No. 3310-40 (certified) temperature and humidity gauges.
- A glass J-tube with a low flow FMI Lab pump was used to introduce test material into the chamber. Filtered laboratory air passed through the J-tube. The air/ vapour mixture entered the top of the chamber where it was diluted with room air. Heating tape was used to heat the air which passed through the J-tube, and glass beads were used to help vaporise the test material.
TEST ATMOSPHERE
- Brief description of analytical method used: no data
- Samples taken from breathing zone: no
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: no data
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks:
- The calculated nominal concentration was 4.9 mg/L. The actual exposure concentration was slightly less than the calculated value due to condensation of the test material.
- Duration of exposure:
- 4 h
- Remarks on duration:
- The exposure period lasted 4 hours after chamber equilibration.
- Concentrations:
- 5.0 mg/L
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes
- Remarks:
- The control group was exposed to filtered room air.
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed once a day during weekdays. Individual animal body weights were measured prior to the treatment, then on days 7 and 14 after exposure. - Necropsy of survivors performed: no data
- Other examinations performed: clinical signs and body weight - Statistics:
- Not used
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 4.9 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality occurred during the 14-day study period.
- Clinical signs:
- other: No clinical signs of toxicity were observed in any of the test animals.
- Body weight:
- No test-materal related effects on body weights.
- Gross pathology:
- No data.
- Other findings:
- No other findings were reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute inhalation toxicity study, conducted according to a former version of OECD test guideline, and in compliance with GLP, no LC50 value was reported due to lack of toxic effect observed in any of the test animals.
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