Decane-1,10-diol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

January - February 1982

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

1981

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Decane-1,10-diol

EC Number:

203-975-2

EC Name:

Decane-1,10-diol

Cas Number:

112-47-0

Molecular formula:

C10H22O2

IUPAC Name:

decane-1,10-diol

Test material form:

solid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Kleintierfarm Madderin AG, 4414 Fuellinsdorf / Switzerland
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 9 weeks
- Weight at study initiation: males = 157-232 g ; females = 154-226 g
- Fasting period before study:
- Housing: in groups of 5
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-2
- Humidity (%): 55+/-10
- Air changes (per hr): "air conditioned" room without details
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

polyethylene glycol

Remarks:

PEG 400

Details on oral exposure:

A dilution of the test compound was prepared using a homogenizer and kept homogenous during treatment using a magnetic stirrer.
Volume d'administration : 10 ml/kg at 1000 mg/kg, 20 ml/kg at 5000 and 10 000 mg/kg.

Doses:

1000, 5000, 10000 mg/kg bw

No. of animals per sex per dose:

5M/5F

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations : daily
- Freqency of weighing: at the day of administration, days 7, days 14 after administration
- Necropsy of survivors and spontaneous death performed: yes

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: mortality observed (20%)

Mortality:

No mortality was observed at 1000 and 5000 mg/kg.
2 males died at 10 000 mg/kg, on day 1 (24 hours after administration)

Clinical signs:

other: The main symptoms observed were: sedation, dyspnea, exophtalmos, curved body position, diarrhea and ruffled fur. Theses symptoms were more prononced in the higher dose groups.

Gross pathology:

No macroscopical organ changes were observed.

Other findings:

no

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral LD50 of the test substance in rats of both sexes observed over a period of 14 days was estimated to be greater than 10 000 mg/kg.

Executive summary:

The test substance was administered orally to rats of both sexes at doses from 1000 to 10 000 mg/kg. No mortality was observed at 1000 and 5000 mg/kg bw in groups of 5 males and 5 females. However 2 males died at 10 000 mg/kg, 24 hours after the administration. The acute oral LD50 of the test substance in rats of both sexes observed over a period of 14 days was estimated to be greater than 10 000 mg/kg.