Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-750-7 | CAS number: 372-31-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November - December 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, non-GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl 4,4,4-trifluoroacetoacetate
- EC Number:
- 206-750-7
- EC Name:
- Ethyl 4,4,4-trifluoroacetoacetate
- Cas Number:
- 372-31-6
- Molecular formula:
- C6H7F3O3
- IUPAC Name:
- ethyl 4,4,4-trifluoro-3-oxobutanoate
- Test material form:
- other: clear liquid
- Details on test material:
- - Name of test material (as cited in study report): P5117
- Physical state: clear, colourless liquid
- Purity test date: 21-Oct-1980
- Expiration date of the lot/batch: no data
- Stability under test conditions: stable
- Storage condition of test material: stored at ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bantin & Kingman Ltd., Grimston, Aldbrough, Nr. Hull
- Age at study initiation: not given
- Weight at study initiation: 125-155 g
- Housing: gang housing; 5 animals per cage in main study
- Diet (e.g. ad libitum): Rat and Mouse No. 1 Modified, BP Nutrition (UK) Ltd., Stepfield, Witham, Essex
- Water (e.g. ad libitum): Tap water
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-25°C
- Humidity (%): ambient humidity
- Photoperiod (hrs dark / hrs light): 12 hours artificial light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test article preparations were administered once only by oral gavage using a metal stomach tube (14 gauge x 8 cm, Stand Medicals Ltd., Manchester) attached to a 2 ml disposable plastic syringe.
- Doses:
- PRETEST:
- 50, 250, 1250 and 5000 mg/kg
MAIN STUDY:
- 400, 566, 800 and 1131 mg/kg - No. of animals per sex per dose:
- PRETEST:
- 2 males & 2 females
MAIN STUDY:
- 5 males & 5 females - Control animals:
- yes
- Details on study design:
- APPEARANCE, BEHAVIOUR AND GENERAL OBSERVATIONS:
All animals were observed for overt signs of toxicity or behavioural change at 0.25, 1, 2 and 4 hours after treatment and subsequently once daily for 14 days. All gross or visible toxic or pharmacological effects were recorded.
BODY WEIGHTS:
Individual body weights were recorded on the day before treatment (Day 1), on the day of treatment and at 7 and 14 days after treatment.
NECROPSY:
Animals dying during the working day were subjected to a gross necropsy examination. Animals surviving at the end of the study were killed by exposure to high levels of carbon dioxide. - Statistics:
- The acute oral median lethal dose (LD50) and 95% fiducial limits for combined male and female groups, were calculated using a pro bit analysis (Finney D.J. (1964), Statistical Method for Biological Assay, 2nd Edition, London, Charles Griffin).
Results and discussion
- Preliminary study:
- The mortalities obsreved in the pretest indicated an LDSO of approximately 1250 mg/kg.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 855 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 741 - 986
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 765 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 630 - 929
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 954 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 801 - 1 135
- Mortality:
- One female treated with 566 mg/kg, 3 animals (1 male, 2 females) treated with 800 mg/kg and 9 animals (4 males, 5 females) treated with 1131 mg/kg died during the observation period. All deaths occurred within 15 minutes and 24 hours after treatment.
- Clinical signs:
- other: 400 mg/kg: Lethargy and hunched posture were evident throughout the day of dosing. All animals appeared normal 24 hours after treatment. 566 mg/kg: All surviving, animals appeared lethargic throughout the day of dosing and this was maintained in 2 animal
- Gross pathology:
- Any animals found dead during the working day were subjected to a gross necropsy examination. Congested lungs and distended stomachs were described in the majority of these animals. One group 8 animal, male 13, treated with 1131 mg/kg showed a mottled appearance of the gastrointestinal tract. No other abnormalities were described.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of P5117 on Wistar rats was found to be:
- combined males and females: 855 mg/kg
- males: 954 mg/kg
- females: 765 mg/kg - Executive summary:
A study was carried out according to EU Method B.1 and OECD Guideline 401 (Acute Oral Toxicity) on Albino Wistar rats. 4 groups of 4 rats (2 male, 2 female) for Dose-Range-Finding and 4 groups of 10 rats (5 male, 5 female) for the main study were treated by gavage with doses from 50 up to 5000 mg/kg in the pretest and 400 up to 1131 mg/kg in the main study. Mortality and a number of clinical signs were observed at mid and high dose group animals of the main study. Animals showed normal body weight gains at the end of the 14 d observation period. At necropsy, there were some tratment related findings noted in the highest dose group only.
The acute oral LD50 of P5117 on Wistar rats was found to be:
- combined males and females: 855 mg/kg
- males: 954 mg/kg
- females: 765 mg/kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.