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EC number: 245-509-0 | CAS number: 23235-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 May 2008 - 12 June 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Study was performed according to the OECD Test Guideline, however no statement of GLP compliance has been made in the test report, and the level of detail contained in the report is limited.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 7827 (Evaluation in an Aqueous Medium of the "Ultimate" Aerobic Biodegradability of Organic Compounds - Method by Analysis of Dissolved Organic Carbon (DOC))
- Deviations:
- no
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Klagshamn waste water plant, Sweden.
- Laboratory culture: Not reported
- Method of cultivation: Not reported
- Storage conditions: Not reported
- Storage length: Not reported
- Preparation of inoculum for exposure: Not reported
- Pretreatment: Not reported
- Concentration of sludge: Not reported
- Initial cell/biomass concentration: 5.9 g suspended solids / L.
- Water filtered: Not reported
- Type and size of filter used, if any: Not reported. A 0.45 µm, OE 67, 45 mm filter was used to filter that water for DOC samples, but no reference is made to filters used to filter inoculum. - Duration of test (contact time):
- 42 d
- Initial conc.:
- 68 mg/L
- Based on:
- formulation
- Initial conc.:
- 42 - 43 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Refer to additional information
- Test temperature: 20 - 25 ºC
- pH: 7.4
- pH adjusted: yes. Media adjusted prior to use
- Aeration of dilution water: All media aerated throughout test.
- Suspended solids concentration: 5.9 g/L (inoculum)
- Continuous darkness: no
- Other:
TEST SYSTEM
- Culturing apparatus:
- Number of culture flasks/concentration: two flasks for test group
- Method used to create aerobic conditions: Air bubbled by an air pump through a tube which ended at the bottom of the flask.
- Measuring equipment: Not specified. DOC and TOC analysis were performed according to the accredited method SS-EN 1484.
- Other:
SAMPLING
- Sampling frequency: DOC determined at 0, 7, 14, 21, 28, 35, and 42 days. TOC determined at days 0 and 28.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Abiotic sterile control: Yes
- Toxicity control: Yes
- Other:
STATISTICAL METHODS: - Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- <= 87
- Sampling time:
- 35 d
- Remarks on result:
- other: Plateau reached after 35 days
- Details on results:
- Test material was incubated beyond 28 days because pass level criterion was almost fulfilled (DOC removal was almost 70% after 28 days).
- Results with reference substance:
- Degredation of greater than 90% was seen after 14 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- The OECD guideline criteria for ready biodegradability were not fulfilled for Di-Trimethylolpropane, and therefore it cannot be considered readily biodegradable. When incubated for 35-42 days, the pass level criterion for inherent biodegradability is fulfilled but the 10-day window is not; according to REACH this eliminates the need for additional testing of biodegradability in inherent tests.
The test substance Di-Trimethylolpropane can therefore be considered inherently biodegradable. - Executive summary:
A ready biodegradability test was performed on the test substance Di-Trimethylolpropane by AnoxKaldnes, Sweden on behalf of Perstorp Speciality Chemicals, Sweden. The test was performed according to ISO and OECD Test Guidelines.
The test substance did not meet the criteria for ready biodegradability over 28 days, and therefore cannot be considered readily biodegradable.
However as removal of DOC had almost reach the 70% mark by the end of the 28 day study period the test was extended in order to investigate the inherent biodegradability of the test substance. When incubated further (for up to 42 days) the test material passed the pass level criterion for inherent biodegradability but not the 10-day window, eliminating the need for further biodegradability testing.
As such the substance should be considered to be inherently biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Robust summary is based on information found on the National Institute of Technology and Evaluation website; no test details could be confirmed.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- not specified
- GLP compliance:
- not specified
- Oxygen conditions:
- not specified
- Inoculum or test system:
- not specified
- Details on inoculum:
- - Initial cell/biomass concentration: 30 mg/L
- Duration of test (contact time):
- 4 wk
- Initial conc.:
- 100 mg/L
- Based on:
- not specified
- Parameter followed for biodegradation estimation:
- TOC removal
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Remarks:
- HPLC
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- Indirect analysis - BOD.
- Parameter:
- % degradation (TOC removal)
- Value:
- 1
- Sampling time:
- 4 wk
- Remarks on result:
- other: Individual values 0, 2, 1%.
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 2
- Sampling time:
- 4 wk
- Remarks on result:
- other: Analysis by HPLC. Individual results 1, 3, 2%.
- Parameter:
- other: BOD
- Value:
- 1
- Sampling time:
- 4 wk
- Remarks on result:
- other: Individual values 1, 0, 2%
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- The test substance 2,2'-Diethyl-2,2'(oxymethyl)bis(propane-1,3-diol) was found to be non-biodegradable under the conditions applied during the test.
- Executive summary:
The result of a biodegredation test on Di-TMP ( 2,2'-Diethyl-2,2'(oxymethyl)bis(propane-1,3-diol), CAS number 23236 -61 -2) was posted on the National Institute of Technology and Evaluation website (www.safe.nite.go.jp). The results was based on a MITI-I test, OECD test guideline 301C and was pusblished in the Official Bulletin of Economy, Trade and Industry on 22 December 2005.
Di-TMP was found to be non-biodegradable under the conditions applied in the test. This can be taken as envidence that Di-TMP is not readily biodegradable.
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Test was performed according to a method equivalent to a relevant OECD test guideline, however no claim of GLP compliance is included in the test report, and the level of detail included in the report is insufficient to confirmcompliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: SS-EN 29 888:1993 "Zahn-Wellen test"
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- Deviations:
- no
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge taken from the Perstorp on-site WWTP (waste water treatment plant).
- Initial cell/biomass concentration: 1 g/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 440 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
TEST SYSTEM
SAMPLING
- Sampling frequency: Samples taken at 0, 12, 24, 36, and 48 hours, and on days 3, 5, 7, 15, 21, and 28.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
STATISTICAL METHODS: - Parameter:
- % degradation (DOC removal)
- Value:
- 90
- Sampling time:
- 28 d
- Details on results:
- Lag time = 0 days.
Rate of biodegredation = 12%/(g SS . day); 46 mg DOC/(g SS . day) - Validity criteria fulfilled:
- not specified
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- The test substance Ditrimethylolpropane was found to be degradable. Degredation of the test substance started without a lag time.
- Executive summary:
A biodegredation study was performed by Anox, Sweden, on behalf of Perstorp, Sweden, to determine the degradability of 19 substances and Waste Water Outlet from the Perstorp on-site waste water treatment plant. One of the substances tested was Di-TMP.
The test was performed in acordance with SS-EN 29 888:1993 "Zahn-Wellen Test", which is identical to OECD method 302B (1992). No claim of GLP compliance was made in the report.
Ditrimethylolpropane
was found to be biodegradable under the conditions applied during the test. Biodegredation commenced without any lag time.
Removal of DOC for Ditrimethylolpropane reached over 90% by the end of the 28 day study period. The result of this study confirms the classification of Ditrimethylolpropane as inherently biodegradable. The pass level of 70% was achieved in 7 days.
Referenceopen allclose all
The quantity of the DOC which was degraded in the flask containing the sample and the reference compound (flask containing the inhibition medium) corresponds to the part that comes from the reference compound. This shows that the test article was not inhibitory to the inoculum.
No removal of DOC in the flask containing the Sterile Medium indicates that no abiotic removal has taken place.
Description of key information
The substance Ditrimethylolpropane is inherently and ultimately biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
- Type of water:
- freshwater
Additional information
The potential for biodegradation of Ditrimethylolpropane was assessed in two studies with further supportive information coming from a Japanese NITE report.
A ready biodegradability test was performed on Di-Trimethylolpropane according to ISO and OECD Test Guidelines.
The test substance did not meet the criteria for ready biodegradability over 28 days, and therefore cannot be considered readily biodegradable.
However when incubated further (for up to 42 days) the test material passed the pass level criterion for inherent biodegradability.As such the substance is considered to be inherently biodegradable.
A further biodegredation study wasin acordance with SS-EN 29 888:1993 "Zahn-Wellen Test", which is identical to OECD method 302B (1992).
Ditrimethylolpropane was found to be biodegradable under the conditions applied during the test. Biodegredation commenced without any lag time.
Removal of DOC for Ditrimethylolpropane reached over 90% by the end of the 28 day study period. The result of this study confirmed the classification of Ditrimethylolpropane as inherently biodegradable. The pass level of 70% was achieved in 7 days.
The result of a biodegredation test on Ditrimethylolpropane was posted on the National Institute of Technology and Evaluation website (www.safe.nite.go.jp). Ditrimethylolpropane was found to be non-biodegradable under the conditions applied in the test. This can be taken as supportive envidence that Ditrimethylolpropane is not readily biodegradable.
Despite the fact that Ditrimethylolpropane was not classified as readily biodegradable its classifcation as inherently biodegradable suggests that it will be significantly removed by biological processes in the STP. It is thus expected that Ditrimethylolpropane will not persist in soil, sediment or in the environment generally.
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