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EC number: 228-528-9 | CAS number: 6289-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-04-14 to 2003-04-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD and GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dimethyl 2,5-dioxocyclohexane-1,4-dicarboxylate
- EC Number:
- 228-528-9
- EC Name:
- Dimethyl 2,5-dioxocyclohexane-1,4-dicarboxylate
- Cas Number:
- 6289-46-9
- Molecular formula:
- C10H12O6
- IUPAC Name:
- 1,4-dimethyl 2,5-dioxocyclohexane-1,4-dicarboxylate
- Details on test material:
- - Name of test material (as cited in study report): DIMETHYLSUCCINYLOSUCCINATE
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 g of the test substance moistened with 1.0 mL deionised water
- Duration of treatment / exposure:
- 4 hours, residual test substance was wiped off with wet Kleenex-tissues
- Observation period:
- animals were examined for erythema/eschar and oedema as well as for other local alterations approximately 1, 24, 48 and 72 hours after patch removal. No further examinations were performed thereafter.
The animals were examined once daily for other than local changes of the skin. - Number of animals:
- 3 rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Mean of 24, 48 and 72h for Animal #: 11/12/13
Erythema / Eschar scores: 0.0/0.0/0.0
Oedema scores: 0.0/0.0/0.0 - Other effects:
- No general toxic effects of the test substance were observed.
All exposed skin sites were normal at each examination term.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- DIMETHYLSUCCINYLOSUCCINATE is neither irritant nor corrosive to skin.
- Executive summary:
The aim of this study was to investigate possible irritation or corrosion by the test substance following a single application to the intact skin of rabbits.
Methods and investigations were performed in accordance with the OECD Guideline 404
0.5 g "DIMETHYLSUCCINYLOSUCCINATE", moistened with deionised water, was applied via a patch to a site of 2.5 cm x 2.5 cm of the intact skin of each of 3 rabbits and covered by a semi-occlusive dressing. The duration of the exposure was 4 hours.
Investigations included: Body weights: at the start and at the termination of the test. General signs of toxicity: once daily. Skin examinations: 1, 24, 48 and 72 h after patch removal (p.a.).
No general toxic effects of the test substance were observed. All exposed skin sites were normal at each examination term.
Based on this findings DIMETHYLSUCCINYLOSUCCINATE is neither irritant nor corrosive to skin.
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