Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-845-6 | CAS number: 13005-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02-12-1982 to 21-12-1982
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- To determine the acute oral LD50 of the test.
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Phenethyl Alcohol
- IUPAC Name:
- Phenethyl Alcohol
- Reference substance name:
- 2-phenylethanol
- EC Number:
- 200-456-2
- EC Name:
- 2-phenylethanol
- Cas Number:
- 60-12-8
- IUPAC Name:
- 2-phenylethanol
- Details on test material:
- - Physical state:Clear liquid
- Stability under test conditions:There was no apparent change in the physical state of the test article during administration.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Blue Spruce Farms, Altamont, New York
- Weight at study initiation: 180-280 grams after fasting
- Fasting period before study: 18 hours
- Housing: Rats were housed individually in stainless steel 1/2" wire mesh cages. Size in accordance with the "Guide for the Care and Use of Laboratory Animals" of the Institute of Laboratory Resources, National Research Council.
- Diet : Wayne Lab Blox, ad libitum, checked daily and added or replaced as needed. Feeders were designed to reduce soiling, bridging, and scattering.
- Water : Availability -fresh tap water, fit for human consumption, ad libitum, using an automatic watering system supplied by Edstrom Industries Inc., Waterford, Wisconsin.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):22±3
- Humidity (%):30 to 70
- Photoperiod (hrs dark / hrs light): 12 hours light, 12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.25% methylcellulose
- Doses:
- 1000, 1600, 2000, 2500 and 3200 mg/kg
- No. of animals per sex per dose:
- Dose-Range-Finding Study: 12, 2 males and 2 females per dose groups
LD50 determination: Fifty (50), 5 males and 5 females per group - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The rats were observed immediately and at one, four and twenty-four hours after dosing and twice daily for fourteen days.
- Necropsy of survivors performed: yes
- Other examinations performed: Body weights,Pharmacotoxic, CNS effects and mortality
Results and discussion
- Preliminary study:
- In the dose-range-finding study, four fasted animals, two per sex, were administered the test article at 500, 1600 and 5000 mg/kg, orally by gavage. Signs observed were body drop, ptosis, diarrhea, decreased activity, decreased body tone, poor grooming, abnormal stance, hypersensitivity, piloerection, chromodacryorrhea and prostration. None of the rats died at the 500 mg/kg level, one rat fied at 1600 mg/kg and four of the rats died at the 5000 mg/kg dose level.
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 609.3 other: mg/kg
- Based on:
- test mat.
- 95% CL:
- 1 399.6 - 1 850.4
- Remarks on result:
- other: LD50 was calculated by Litchfield and Wilcox method
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 692.6 other: mg/kg
- Based on:
- test mat.
- 95% CL:
- 1 433.3 - 1 998.9
- Remarks on result:
- other: LD50 was calculated by Litchfield and Wilcox method
- Mortality:
- None of the animals died at the 1000 mg/kg dose level, five of the ten died at the 1600 mg/kg dose level, nine of ten died at 2000 mg/kg and ten of ten died at the 2500 mg/kg and 3200 mg/kg dose levels. .See table 2 for detail.
- Clinical signs:
- other: Sings observed included diarrhea, decreased activity, poor grooming, piloerection, exophthalmus, ataxia, chromodacryorrhea, hypersensitivity, hyperactivity, decreased body tone, tremors, dyspena, wheezing, prostration, abnormal stance, ptosis, abnormal ga
- Gross pathology:
- Necropsy of animals dying on study revealed disteneded stomachs with hemorrhages of the gladular mucosa. Ref foci on the thymus, discoloured adrenals and fluid-filled bladders were also observed. Terminal necropsy revealed no visable lesions in the remaining animals.
Any other information on results incl. tables
Table 2. Summary of Mortality
Dose mg/kg |
Sex |
No.of Rats |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
Total Mortality |
1000 |
M |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/5 |
1000 |
F |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/5 |
1600 |
M |
5 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2/5 |
1600 |
F |
5 |
2 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3/5 |
2000 |
M |
5 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
4/5 |
2000 |
F |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5/5 |
2500 |
M |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5/5 |
2500 |
F |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5/5 |
3200 |
M |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5/5 |
3200 |
F |
5 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5/5 |
Table 3. Onset and duration of signs at 1600 mg/kg in Males
Post Dose |
Signs Observed |
Immediate |
Semi-prostration, prostration body drop |
1 Hour |
Body drop, ataxia, abnormal gait |
4 Hour |
Body drop, abnormal gait, decreased activity |
Day 1 |
Semi-prostration, prostration, piloerection, body drop, abnormal gait, decreased activity, diarrhea |
Day 2 |
Arched back, abnormal gait, piloerection |
Day 3 |
Arched back, piloerection |
Day 4 |
Arched back, abnormal gait, piloerection, slight ptosis |
Day 5 |
Piloerection, body drop |
Day 6 |
Piloerection, abnormal gait, body drop |
Day 7 |
Piloerection, body drop |
Day 8 |
Piloerection, wheezing |
Day 9-14 |
No signs |
Table 4. Onset and Duration of signs at 1600 mg/kg in females
Post Dose |
Signs Observed |
Immediate |
Prostration, dyspnea, hyperactivity, body drop |
1 Hour |
Semi- prostration |
4 Hour |
Prostation, body drop, decreased activity |
Day 1 |
Piloerection, decreased body tone, ataxia, body drop, diarrhea |
Day 2 |
Semi-prostration, abnormal gait, piloerection, arched back |
Day 3 |
Semi-prostration ,arched back, piloerection |
Day 4 |
Arched back, piloerection, abnormal stance |
Day 5-14 |
No signs |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Based upon the results of the acute oral acute oral toxicity study in rats, the calculated acute oral LD50 for male and female treated with Phenethyl alcohol was determined to be 1609.3 mg/kg with confidence limits of 1399.6 to 1850.4 mg/kg. The calculated acute oral LD50 for males was determined to be 1692.6 mg/kg with 95% confidence limits of 1433.3 to 1998.9 mg/kg. An attempt was made to calculate the acute oral LD50 in females but the data generated did not lend itself to the method of Litchfield and Wilcoxon.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.